Two novel tumours with NTRK2 fusion in the methylation class of extraventricular neurocytomas, including one intraventricular.

Autor: Uro-Coste E; Department of Pathology, Toulouse University Hospital, Toulouse, France.; INSERM U1037, Cancer Research Center of Toulouse (CRCT), Toulouse, France., Tauziede-Espariat A; GHU Psychiatrie et Neurosciences, Site Sainte-Anne, Service de Neuropathologie, Paris, France.; Institut de Psychiatrie et Neurosciences de Paris (IPNP), UMR_S1266, INSERM, Equipe IMA-BRAIN (Imaging Biomarkers for Brain Development and Disorders), University of Paris, Paris, France., Dubucs C; Department of Pathology, Toulouse University Hospital, Toulouse, France., Chiforeanu DC; Department of Pathology, Rennes University Hospital, Rennes, France., Siegfried A; Department of Pathology, Toulouse University Hospital, Toulouse, France.; INSERM U1037, Cancer Research Center of Toulouse (CRCT), Toulouse, France., Nicaise Y; INSERM U1037, Cancer Research Center of Toulouse (CRCT), Toulouse, France., Bauchet L; Department of Neurosurgery, Montpellier University Hospital, Montpellier, France.; Institute for Neuroscience of Montpellier (IGF), INSERM U1051, Montpellier University Hospital, Montpellier, France., Riffaud L; Department of Neurosurgery, University Hospital, Rennes, France., Bielle F; Department of Neuropathology, AP-HP, Hôpitaux Universitaires Pitié-Salpêtrière Charles Foix, Paris, France.; Sorbonne University, UPMC, University of Paris, Paris, France.; Brain and Spine Institute (ICM; INSERM, UMRS 1127; CNRS, UMR 7225), Paris, France., Vasiljevic A; Department of Neuropathology, Groupe Hospitalier Est, Hospices Civils de Lyon, Bron, France.; Claude Bernard University Lyon 1, Lyon, France., Appay R; APHM, CHU Timone, Service d'Anatomie Pathologique et de Neuropathologie, Marseille, France.; Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France., Evrard S; Department of Pathology, Toulouse University Hospital, Toulouse, France.; INSERM U1037, Cancer Research Center of Toulouse (CRCT), Toulouse, France., Varlet P; GHU Psychiatrie et Neurosciences, Site Sainte-Anne, Service de Neuropathologie, Paris, France.; Institut de Psychiatrie et Neurosciences de Paris (IPNP), UMR_S1266, INSERM, Equipe IMA-BRAIN (Imaging Biomarkers for Brain Development and Disorders), University of Paris, Paris, France., Rigau V; Institute for Neuroscience of Montpellier (IGF), INSERM U1051, Montpellier University Hospital, Montpellier, France.; Department of Pathology, Montpellier University Hospital, Montpellier, France.
Jazyk: angličtina
Zdroj: Brain pathology (Zurich, Switzerland) [Brain Pathol] 2024 May; Vol. 34 (3), pp. e13223. Date of Electronic Publication: 2023 Nov 23.
DOI: 10.1111/bpa.13223
Abstrakt: We report here about two novel tumours classified as extraventricular neurocytomas (EVN) using DNA-methylation profiling, associated with NTRK2 fusions instead of the usual FGFR1 alterations so far attributed to this tumoural entity. We present the second detailed case of an intraventricular presentation in the MC EVN. Our findings broaden the spectrum of MC EVN and have implications in terms of diagnosis, therapy and terminology.
(© 2023 The Authors. Brain Pathology published by John Wiley & Sons Ltd on behalf of International Society of Neuropathology.)
Databáze: MEDLINE
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