Neurovascular coupling in early stage dementia - A case-control study.

Autor:	van Dijk SE; Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands., Drenth N; Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands., Hafkemeijer A; Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.; Institute of Psychology, Leiden University, Leiden, The Netherlands.; Leiden Institute for Brain and Cognition, Leiden, The Netherlands., Labadie G; Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands., Witjes-Ané MW; Department of Geriatrics and Psychiatrics, Leiden University Medical Center, Leiden, the Netherlands., Blauw GJ; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.; Department of Geriatrics, Haaglanden Medical Center, The Hague, the Netherlands., Rombouts SA; Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.; Institute of Psychology, Leiden University, Leiden, The Netherlands.; Leiden Institute for Brain and Cognition, Leiden, The Netherlands., van der Grond J; Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands., van Rooden S; Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
Jazyk:	angličtina
Zdroj:	Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism [J Cereb Blood Flow Metab] 2024 Jun; Vol. 44 (6), pp. 1013-1023. Date of Electronic Publication: 2023 Nov 22.
DOI:	10.1177/0271678X231214102
Abstrakt:	Cerebral amyloid angiopathy (CAA) is frequently found post mortem in Alzheimer's dementia, but often undetected during life especially since in vivo hallmarks of CAA and its vascular damage become overt relatively late in the disease process. Decreased neurovascular coupling to visual stimulation has been put forward as an early MRI marker for CAA disease severity. The current study investigates the role of neurovascular coupling in AD related dementia and its early stages. We included 25 subjective cognitive impairment, 33 mild cognitive impairment and 17 dementia patients and 44 controls. All participants underwent magnetic resonance imaging of the brain and neuropsychological assessment. Univariate general linear modeling analyses were used to assess neurovascular coupling between patient groups and controls. Moreover, linear regression analyses was used to assess the associations between neurovascular coupling and cognition. Our data show that BOLD amplitude is lower in dementia (mean 0.8 ± 0.2, p = 0.001) and MCI patients (mean 0.9 ± 0.3, p = 0.004) compared with controls (mean 1.1 ± 0.2). A low BOLD amplitude was associated with low scores in multiple cognitive domains. We conclude that cerebrovascular dysfunction, most likely due CAA, is an important comorbidity in early stages of dementia and has an independent effect on cognition. Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze:	MEDLINE
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