Coordination function index: A novel indicator for assessing hindlimb locomotor recovery in spinal cord injury rats based on catwalk gait parameters.

Autor: Liu S; Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China; International Science and Technology Cooperation Base of Spinal Cord lnjury, Tianjin, China; Tianjin Key Laboratory of Spine and Spinal Cord Injury, Tianjin, China., Wu Q; Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China; International Science and Technology Cooperation Base of Spinal Cord lnjury, Tianjin, China; Tianjin Key Laboratory of Spine and Spinal Cord Injury, Tianjin, China., Wang L; Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China; International Science and Technology Cooperation Base of Spinal Cord lnjury, Tianjin, China; Tianjin Key Laboratory of Spine and Spinal Cord Injury, Tianjin, China., Xing C; Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China; International Science and Technology Cooperation Base of Spinal Cord lnjury, Tianjin, China; Tianjin Key Laboratory of Spine and Spinal Cord Injury, Tianjin, China., Guo J; Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China; International Science and Technology Cooperation Base of Spinal Cord lnjury, Tianjin, China; Tianjin Key Laboratory of Spine and Spinal Cord Injury, Tianjin, China., Li B; Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China; International Science and Technology Cooperation Base of Spinal Cord lnjury, Tianjin, China; Tianjin Key Laboratory of Spine and Spinal Cord Injury, Tianjin, China., Ma H; Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China; International Science and Technology Cooperation Base of Spinal Cord lnjury, Tianjin, China; Tianjin Key Laboratory of Spine and Spinal Cord Injury, Tianjin, China., Zhong H; Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China; International Science and Technology Cooperation Base of Spinal Cord lnjury, Tianjin, China; Tianjin Key Laboratory of Spine and Spinal Cord Injury, Tianjin, China., Zhou M; Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China; International Science and Technology Cooperation Base of Spinal Cord lnjury, Tianjin, China; Tianjin Key Laboratory of Spine and Spinal Cord Injury, Tianjin, China., Zhu S; Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China; International Science and Technology Cooperation Base of Spinal Cord lnjury, Tianjin, China; Tianjin Key Laboratory of Spine and Spinal Cord Injury, Tianjin, China., Zhu R; Department of Spine Surgery, Tianjin Union Medical Center, Nankai University, Tianjin, China., Ning G; Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China; International Science and Technology Cooperation Base of Spinal Cord lnjury, Tianjin, China; Tianjin Key Laboratory of Spine and Spinal Cord Injury, Tianjin, China. Electronic address: gzning@tmu.edu.cn.
Jazyk: angličtina
Zdroj: Behavioural brain research [Behav Brain Res] 2024 Feb 29; Vol. 459, pp. 114765. Date of Electronic Publication: 2023 Nov 20.
DOI: 10.1016/j.bbr.2023.114765
Abstrakt: In preclinical studies of spinal cord injury (SCI), behavioral assessments are crucial for evaluating treatment effectiveness. Commonly used methods include Basso, Beattie, Bresnahan (BBB) score and the Louisville swim scale (LSS), relying on subjective observations. The CatWalk automated gait analysis system is also widely used in SCI studies, providing extensive gait parameters from footprints. However, these parameters are often used independently or combined simply without utilizing the vast amount of data provided by CatWalk. Therefore, it is necessary to develop a novel approach encompassing multiple CatWalk parameters for a comprehensive and objective assessment of locomotor function. In this work, we screened 208 CatWalk XT gait parameters and identified 38 suitable for assessing hindlimb motor function recovery in a rat thoracic contusion SCI model. Exploratory factor analysis was used to reveal structural relationships among these parameters. Weighted scores for Coordination effectively differentiated hindlimb motor function levels, termed as the Coordinated Function Index (CFI). CFI showed high reliability, exhibiting high correlations with BBB scores, LSS, and T2WI lesion area. Finally, we simplified CFI based on factor loadings and correlation analysis, obtaining a streamlined version with reliable assessment efficacy. In conclusion, we developed a systematic assessment indicator utilizing multiple CatWalk parameters to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI.
Competing Interests: Declaration of Competing Interest The authors declare that they have no conflict of interest.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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