Age-Related Macular Degeneration in Patients with Androgenetic Alopecia: Could the Monocyte/HDL Ratio Be the Link?

Autor:	Shams GM; Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Benha University, Benha, Egypt., Saleh AA; Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Benha University, Benha, Egypt., Saeed AM; Department of Ophthalmology, Faculty of Medicine, Benha University, Benha, Egypt., El-Damaty SN; Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Benha University, Benha, Egypt., Abdel-Ghaffar AO; Department of Clinical and Chemical Pathology, Faculty of Medicine, Benha University, Benha, Egypt.
Jazyk:	angličtina
Zdroj:	Dermatology practical & conceptual [Dermatol Pract Concept] 2023 Oct 01; Vol. 13 (4). Date of Electronic Publication: 2023 Oct 01.
DOI:	10.5826/dpc.1304a285
Abstrakt:	Introduction: Both Androgenetic alopecia (AGA) and age-related macular degeneration (AMD) shared the microinflammatory milieu and increased oxidative stress as important criteria in their pathogenesis. The monocyte/high density lipoprotein (HDL) ratio (MHR) seems to be an easy-to-calculate prognostic marker of microinflammation. Objectives: To assess MHR in patients with AGA and its correlation to AMD in these patients, if any. Methods: Forty patients with AGA aged 40 years or more of both sexes and 40 control subjects participated in this case-control study. General, dermatological, and ophthalmologic examination, MHR evaluation and optical coherence tomography (OCT) were performed. Results: The mean MHR was significantly higher in AGA patients (6.98 ± 2.21) than in controls (3.82 ± 0.68) (P < 0.001). AMD was significantly higher in patients than controls (P < 0.001). Eighty percent of AGA patients were diagnosed with AMD versus 20% of control subjects. The presence of AMD in AGA was significantly related to the degree of severity of AGA in male patients (P = 0.02). The MHR was significantly higher in AGA patients found to have AMD (9.37 ± 1.1 and 7.01 ± 1.42 in the wet and dry type respectively) than those without AMD (P < 0.001). Conclusions: AMD may develop more frequently in those with AGA. The MHR seems to be a missing link between both conditions, and could be utilized as a potential biomarker for predicting AMD in AGA patients.
Databáze:	MEDLINE
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