Burden of AML, 1990-2019: Estimates From the Global Burden of Disease Study.

Autor:	Jani CT; Sylvester Comprehensive Cancer Center at University of Miami, Miami, FL.; Department of Medicine, Mount Auburn Hospital, Harvard Medical School, Cambridge, MA.; Department of Medicine, Harvard Medical School, Boston, MA.; M.D.R Collaborative Group, London, United Kingdom., Ahmed A; Department of Medicine, Mount Auburn Hospital, Harvard Medical School, Cambridge, MA.; Department of Medicine, Harvard Medical School, Boston, MA.; M.D.R Collaborative Group, London, United Kingdom., Singh H; M.D.R Collaborative Group, London, United Kingdom.; Department of Pulmonary and Critical Care, Medical College of Wisconsin, Milwaukee, WI., Mouchati C; M.D.R Collaborative Group, London, United Kingdom.; Department of Neurology, Cleveland Clinic, Cleveland, OH., Al Omari O; Department of Medicine, Mount Auburn Hospital, Harvard Medical School, Cambridge, MA.; Department of Medicine, Harvard Medical School, Boston, MA.; M.D.R Collaborative Group, London, United Kingdom.; Department of Pulmonary and Critical Care, Temple University, Philadelphia, PA., Bhatt PS; Department of Medicine, Mount Auburn Hospital, Harvard Medical School, Cambridge, MA.; Department of Medicine, Harvard Medical School, Boston, MA.; M.D.R Collaborative Group, London, United Kingdom., Sharma R; Humanities and Social Science, National Institute of Technology Kurukshetra, Haryana, India., Farooq M; King Edward Medical University, Lahore, Pakistan., Liu W; Department of Medicine, Mount Auburn Hospital, Harvard Medical School, Cambridge, MA.; Department of Medicine, Harvard Medical School, Boston, MA., Shalhoub J; M.D.R Collaborative Group, London, United Kingdom.; Academic Section of Vascular Surgery, Department of Surgery and Cancer, Imperial College London, London, United Kingdom., Marshall D; M.D.R Collaborative Group, London, United Kingdom.; Critical Care Research Group, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom., Salciccioli JD; Department of Medicine, Harvard Medical School, Boston, MA.; M.D.R Collaborative Group, London, United Kingdom.; Department of Pulmonary and Critical Care, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Warner JL; Center for Clinical Cancer Informatics and Data Science, Legorreta Cancer Center, Brown University, Providence, RI.; Lifespan Cancer Institute, Rhode Island Hospital, Providence, RI., Lam P; Department of Medicine, Mount Auburn Hospital, Harvard Medical School, Cambridge, MA.; Department of Medicine, Harvard Medical School, Boston, MA.; Division of Hematology and Oncology, Mount Auburn Hospital, Harvard Medical School, Cambridge, MA.
Jazyk:	angličtina
Zdroj:	JCO global oncology [JCO Glob Oncol] 2023 Sep; Vol. 9, pp. e2300229.
DOI:	10.1200/GO.23.00229
Abstrakt:	Purpose: AML accounts for 80% of acute leukemia in adults. While progress has been made in treating younger patients in the past 2 decades, there has been limited improvement for older patients until recently. This study examines the global and European Union (EU) 15+ trends in AML between 1990 and 2019. Methods: We extracted age-standardized incidence rates (ASIRs), age-standardized death rates (ASMRs), and disability-adjusted life years, stratified by sex from the Global Burden of Disease Study database, and mortality-to-incidence ratio (MIR) were computed. Trends were compared using Joinpoint regression. Results: The findings show a global increase in AML incidence for both sexes from 1990 to 2019. In the EU15+ countries, most countries exhibited an increase in ASIR for both sexes. Joinpoint revealed that globally for male patients, ASIR steadily increased until 2010, remained stable until 2015 followed by a decline till 2019. Similar trends were observed in female patients. For ASMR, although there was an increase globally and in most EU15+ countries, there was a statistically significant decrease in mortality rates globally and in the majority of EU15+ countries in recent years. MIR improved in both sexes globally. On age stratification, AML burden was highest among older groups (55 years and older), while the lowest rates were observed in younger than 20 years. Conclusion: The findings from our study indicate a global rise in AML incidence and mortality in both sexes and decrease in MIR from 1990 to 2019 suggesting a better survival. However, on Joinpoint analysis, there is no change in MIR in women in the past decade and past 4 years in men indicating plateau in survival trends despite recent advances.
Databáze:	MEDLINE
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