The economic burden of Chagas disease: A systematic review.

Autor: Andrade MV; Department of Economics, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Noronha KVMS; Department of Economics, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., de Souza A; Faculty of Economic Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Motta-Santos AS; Center for Health Technology Assessment, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.; Center for Development and Regional Planning, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Braga PEF; Faculty of Economic Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Bracarense H; Faculty of Economic Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., de Miranda MCC; Faculty of Economic Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Nascimento BR; Department of Internal Medicine, Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.; Telehealth Center and Cardiology Service, Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Molina I; International Health Unit Vall d'Hebron-Drassanes, Infectious Diseases Department, Vall d'Hebron University Hospital, Barcelona, Spain., Martins-Melo FR; Federal Institute of Education, Science and Technology of Ceará, Fortaleza, Brazil., Perel P; World Heart Federation, Geneva, Switzerland., Geissbühler Y; Novartis Global Health, Basel, Switzerland., Quijano M; Novartis Global Health, Basel, Switzerland., Machado IE; Department of Family Medicine, Mental and Collective Health, Universidade Federal de Ouro Preto, Ouro Preto, Brazil., Ribeiro ALP; Department of Internal Medicine, Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.; Telehealth Center and Cardiology Service, Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Jazyk: angličtina
Zdroj: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2023 Nov 22; Vol. 17 (11), pp. e0011757. Date of Electronic Publication: 2023 Nov 22 (Print Publication: 2023).
DOI: 10.1371/journal.pntd.0011757
Abstrakt: Background: Chagas disease (CD) is a neglected disease affecting millions worldwide, yet little is known about its economic burden. This systematic review is part of RAISE project, a broader study that aims to estimate the global prevalence, mortality, and health and economic burden attributable to chronic CD and Chronic Chagas cardiomyopathy. The objective of this study was to assess the main costs associated with the treatment of CD in both endemic and non-endemic countries.
Methods: An electronic search of the Medline, Lilacs, and Embase databases was conducted until 31st, 2022, to identify and select economic studies that evaluated treatment costs of CD. No restrictions on place or language were made. Complete or partial economic analyses were included.
Results: Fifteen studies were included, with two-thirds referring to endemic countries. The most commonly investigated cost components were inpatient care, exams, surgeries, consultation, drugs, and pacemakers. However, significant heterogeneity in the estimation methods and presentation of data was observed, highlighting the absence of standardization in the measurement methods and cost components. The most common component analyzed using the same metric was hospitalization. The mean annual hospital cost per patient ranges from $25.47 purchasing power parity US dollars (PPP-USD) to $18,823.74 PPP-USD, and the median value was $324.44 PPP-USD. The lifetime hospital cost per patient varies from $209,44 PPP-USD for general care to $14,351.68 PPP-USD for patients with heart failure.
Discussion: Despite the limitations of the included studies, this study is the first systematic review of the costs of CD treatment. The findings underscore the importance of standardizing the measurement methods and cost components for estimating the economic burden of CD and improving the comparability of cost components magnitude and cost composition analysis. Finally, assessing the economic burden is essential for public policies designed to eliminate CD, given the continued neglect of this disease.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2023 Andrade et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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