NANOPARTICLES AND COLORECTAL CANCER: CAN THE USE OF METAL NANOPARTICLE COMPOSITIONS AFFECT OXIDATIVE STRESS MARKERS AND COLON HISTOLOGICAL CHANGES UNDER DMH-INDUCED CARCINOGENESIS.

Autor: Soroka Y; 1Department of Anesthesiology and Intensive-Care Medicine, I. Horbachevsky Ternopil National Medical University, Ukraine., Kramar S; 2Department of Histology and Embryology, I. Horbachevsky Ternopil National Medical University, Ukraine., Smahlii Z; 3Department of Infectious Diseases with Epidemiology, Dermatology, and Venerology, I. Horbachevsky Ternopil National Medical University, Ukraine., Lyebyedyeva T; 4Department of Physiology, Bioethics and Biosafety, I. Horbachevsky Ternopil National Medical University, Ukraine., Kvasha Y; 5Central Research Lab, I. Horbachevsky Ternopil National Medical University, Ukraine., Andriichuk I; 5Central Research Lab, I. Horbachevsky Ternopil National Medical University, Ukraine., Nebesna Z; 2Department of Histology and Embryology, I. Horbachevsky Ternopil National Medical University, Ukraine., Lisnychuk N; 5Central Research Lab, I. Horbachevsky Ternopil National Medical University, Ukraine.
Jazyk: angličtina
Zdroj: Georgian medical news [Georgian Med News] 2023 Sep (342), pp. 11-20.
Abstrakt: Colorectal cancer (CRC) - a significant global health challenge. Exploring biological markers of oxidative stress is crucial, as they can play an essential role in initiating the transition from an organ's "healthy state" to a "malignant injury." There is substantial promise in investigating the level of 8-isoprostane (8-isoPGF2α) as a novel and dependable marker of oxidative stress. This paper presents that 8-isoprostane levels have been linked to the development of severe structural changes in the colon wall, accompanied by endogenic intoxication syndrome. The obtained results prove the strong connection between oxidative stress and carcinogenesis progression. Our research further illustrates the favorable and potentially beneficial impact of the Au/Ag/Fe NPs composition, which can find utility in a diverse range of contemporary applications.
Databáze: MEDLINE
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