Single-Step Synthesis of γ-Ketoacids through a Photoredox-Catalyzed Dual Decarboxylative Coupling of α-Oxo Acids and Maleic Anhydrides.
| Autor: | Davies AM; Department of Chemistry, The University of Kansas, 1567 Irving Hill Rd., Lawrence, Kansas 66045, United States., Londhe SS; Department of Chemistry, The University of Kansas, 1567 Irving Hill Rd., Lawrence, Kansas 66045, United States., Smith ER; Department of Chemistry, The University of Kansas, 1567 Irving Hill Rd., Lawrence, Kansas 66045, United States., Tunge JA; Department of Chemistry, The University of Kansas, 1567 Irving Hill Rd., Lawrence, Kansas 66045, United States. |
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| Jazyk: | angličtina |
| Zdroj: | Organic letters [Org Lett] 2023 Dec 08; Vol. 25 (48), pp. 8634-8639. Date of Electronic Publication: 2023 Nov 22. |
| DOI: | 10.1021/acs.orglett.3c03258 |
| Abstrakt: | A photocatalytic methodology for the single step synthesis of γ-ketoacids from α-ketoacids has been developed. This method employs maleic anhydrides as traceless synthetic equivalents of acrylic acids, achieving a selective cross-coupling via a dual decarboxylative strategy, where molecular CO |
| Databáze: | MEDLINE |
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