Alternative protein encapsulation with MOFs: overcoming the elusive mineralization of HKUST-1 in water.
| Autor: | Díaz JC; Instituto de Ciencia Molecular (ICMol), Universidad de Valencia, Catedrático José Beltrán 2, 46980 Paterna, Valencia, Spain. monica.gimenez-marques@uv.es., Giménez-Marqués M; Instituto de Ciencia Molecular (ICMol), Universidad de Valencia, Catedrático José Beltrán 2, 46980 Paterna, Valencia, Spain. monica.gimenez-marques@uv.es. |
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| Jazyk: | angličtina |
| Zdroj: | Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2023 Dec 19; Vol. 60 (1), pp. 51-54. Date of Electronic Publication: 2023 Dec 19. |
| DOI: | 10.1039/d3cc04320g |
| Abstrakt: | Protein encapsulation by in situ formation of MOFs is a valuable strategy to immobilise and protect these bioentities. However the required biocompatible conditions limits the scope of MOFs under investigation, particularly in the case of hydrolytically unstable MOFs such as HKUST-1. We report alternative synthetic procedures to obtain protein@HKUST-1 biocomposites from related Cu-BTC dense biocomposites. pH dependent dense phase precursors are first obtained and their transformations into HKUST-1 are characterized. Encapsulation efficiency is affected by the protein's nature, and can be modulated by the sequential or simultaneous addition of MOF precursors. |
| Databáze: | MEDLINE |
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