Central macular morphology and optic nerve fibre layer thickness in young adults born premature and screened for retinopathy of prematurity.

Autor: Pétursdóttir D; Department of Surgical Sciences/Ophthalmology, Uppsala University, Uppsala, Sweden.; Department of Ophthalmology, Faculty of Medicine, National University Hospital, University of Iceland, Reykjavík, Iceland., Åkerblom H; Department of Surgical Sciences/Ophthalmology, Uppsala University, Uppsala, Sweden.; Centre for Clinical Research Västmanland, Hospital of Västmanland, Västerås, Sweden., Holmström G; Department of Surgical Sciences/Ophthalmology, Uppsala University, Uppsala, Sweden., Larsson E; Department of Surgical Sciences/Ophthalmology, Uppsala University, Uppsala, Sweden.
Jazyk: angličtina
Zdroj: Acta ophthalmologica [Acta Ophthalmol] 2024 Jun; Vol. 102 (4), pp. 391-400. Date of Electronic Publication: 2023 Nov 22.
DOI: 10.1111/aos.15814
Abstrakt: Purpose: To investigate central retinal morphology and optic retinal nerve fibre layer (RNFL) in prematurely born young adults and compare to term born controls.
Materials and Methods: The participants were 59 prematurely born individuals, with a birthweight ≤1.500 g, and 44 term born controls, all 25-29 years of age. Visual acuity (VA) and contrast sensitivity (CS) were assessed. The retinal macular thickness, ganglion cell-inner plexiform layer (GC-IPL) thickness and RNFL thickness were assessed with Cirrus optical coherence tomography (OCT).
Results: Central macular thickness was increased (mean 26.7 μm) in prematurely born individuals compared to controls. The macular GC-IPL was thinner (mean 3.84 μm), also when excluding those with previous retinopathy of prematurity (ROP) and those with neurological complications. Gestational age at birth and previous treatment of ROP were risk factors for a thicker macula, however, not for reduced GC-IPL. The average peripapillary RNFL was thinner (mean 4.61 μm) in the prematurely born individuals, also when excluding those with previous ROP and/or neurological complications. Within the prematurely born group, treated ROP was correlated with increased average RNFL. Further, both better VA and CS were associated with thinner optic nerve RNFL and thicker average GC-IPL.
Conclusion: Macular and optic nerve morphology were influenced by premature birth as assessed with OCT in adult individuals. Gestational age at birth and treatment for ROP seemed to affect central macular thickness, and treated ROP affected the peripapillary RNFL. Thus, retinal sequelae remained in adulthood.
(© 2023 The Authors. Acta Ophthalmologica published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation.)
Databáze: MEDLINE
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