Pediatric HIV+ Kaposi sarcoma exhibits clinical, virological, and molecular features different from the adult disease.

Autor:	Caro-Vegas C; UNC Lineberger Comprehensive Cancer Center and Center for AIDS Research, Chapel Hill, North Carolina, USA., Peng A; UNC Lineberger Comprehensive Cancer Center and Center for AIDS Research, Chapel Hill, North Carolina, USA., Juarez A; UNC Lineberger Comprehensive Cancer Center and Center for AIDS Research, Chapel Hill, North Carolina, USA., Silverstein A; Texas Children's Cancer & Hematology Center Global HOPE (Hematology-Oncology Pediatric Excellence) Program Malawi, Lilongwe, Malawi.; University of Colorado, Department of Pediatrics, Denver, Colorado, USA., Kamiyango W; Texas Children's Cancer & Hematology Center Global HOPE (Hematology-Oncology Pediatric Excellence) Program Malawi, Lilongwe, Malawi., Villiera J; Texas Children's Cancer & Hematology Center Global HOPE (Hematology-Oncology Pediatric Excellence) Program Malawi, Lilongwe, Malawi., McAtee CL; Texas Children's Cancer & Hematology Center Global HOPE (Hematology-Oncology Pediatric Excellence) Program Malawi, Lilongwe, Malawi.; Baylor College of Medicine (BCM), Department of Pediatrics, Houston, Texas, USA.; Texas Children's Hospital Cancer & Hematology Center, Houston, Texas, USA., Mzikamanda R; Texas Children's Cancer & Hematology Center Global HOPE (Hematology-Oncology Pediatric Excellence) Program Malawi, Lilongwe, Malawi., Tomoka T; University of North Carolina Project-Malawi, Kamuzu Central Hospital Pathology Laboratory, Lilongwe, Malawi., Peckham-Gregory EC; Texas Children's Cancer & Hematology Center Global HOPE (Hematology-Oncology Pediatric Excellence) Program Malawi, Lilongwe, Malawi.; Baylor College of Medicine (BCM), Department of Pediatrics, Houston, Texas, USA.; Texas Children's Hospital Cancer & Hematology Center, Houston, Texas, USA., Moorad R; UNC Lineberger Comprehensive Cancer Center and Center for AIDS Research, Chapel Hill, North Carolina, USA., Kovarik CL; University of Pennsylvania, Philadelphia, Pennsylvania, USA., Campbell LR; Baylor College of Medicine (BCM), Department of Pediatrics, Houston, Texas, USA.; BCM International Pediatric AIDS Initiative Children's Foundation Tanzania, Mbeya, Tanzania., Mehta PS; Texas Children's Cancer & Hematology Center Global HOPE (Hematology-Oncology Pediatric Excellence) Program Malawi, Lilongwe, Malawi.; Baylor College of Medicine (BCM), Department of Pediatrics, Houston, Texas, USA.; Texas Children's Hospital Cancer & Hematology Center, Houston, Texas, USA., Kazembe PN; BCM International Pediatric AIDS Initiative Children's Foundation Malawi, Lilongwe, Malawi., Allen CE; Texas Children's Cancer & Hematology Center Global HOPE (Hematology-Oncology Pediatric Excellence) Program Malawi, Lilongwe, Malawi.; Baylor College of Medicine (BCM), Department of Pediatrics, Houston, Texas, USA.; Texas Children's Hospital Cancer & Hematology Center, Houston, Texas, USA., Scheurer ME; Texas Children's Cancer & Hematology Center Global HOPE (Hematology-Oncology Pediatric Excellence) Program Malawi, Lilongwe, Malawi.; Baylor College of Medicine (BCM), Department of Pediatrics, Houston, Texas, USA.; Texas Children's Hospital Cancer & Hematology Center, Houston, Texas, USA., Ozuah NW; Texas Children's Cancer & Hematology Center Global HOPE (Hematology-Oncology Pediatric Excellence) Program Malawi, Lilongwe, Malawi.; Baylor College of Medicine (BCM), Department of Pediatrics, Houston, Texas, USA.; Texas Children's Hospital Cancer & Hematology Center, Houston, Texas, USA., Dittmer DP; UNC Lineberger Comprehensive Cancer Center and Center for AIDS Research, Chapel Hill, North Carolina, USA., El-Mallawany NK; Texas Children's Cancer & Hematology Center Global HOPE (Hematology-Oncology Pediatric Excellence) Program Malawi, Lilongwe, Malawi.; Baylor College of Medicine (BCM), Department of Pediatrics, Houston, Texas, USA.; Texas Children's Hospital Cancer & Hematology Center, Houston, Texas, USA.
Jazyk:	angličtina
Zdroj:	JCI insight [JCI Insight] 2023 Nov 22; Vol. 8 (22). Date of Electronic Publication: 2023 Nov 22.
DOI:	10.1172/jci.insight.167854
Abstrakt:	BACKGROUNDKaposi sarcoma (KS) is among the most common childhood cancers in Eastern and Central Africa. Pediatric KS has a distinctive clinical presentation compared with adult KS, which includes a tendency for primary lymph node involvement, a considerable proportion of patients lacking cutaneous lesions, and a potential for fulminant disease. The molecular mechanisms or correlates for these disease features are unknown.METHODSThis was a cross-sectional study. All cases were confirmed by IHC for KS-associated herpesvirus (KSHV) LANA protein. Baseline blood samples were profiled for HIV and KSHV genome copy numbers by qPCR and secreted cytokines by ELISA. Biopsies were characterized for viral and human transcription, and KSHV genomes were determined when possible.RESULTSSeventy participants with pediatric KS were enrolled between June 2013 and August 2019 in Malawi and compared with adult patients with KS. They exhibited high KSHV genome copy numbers and IL-6/IL-10 levels. Four biopsies (16%) had a viral transcription pattern consistent with lytic viral replication.CONCLUSIONThe unique features of pediatric KS may contribute to the specific clinical manifestations and may direct future treatment options.FUNDINGUS National Institutes of Health U54-CA-254569, PO1-CA019014, U54-CA254564, RO1-CA23958.
Databáze:	MEDLINE
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