Characterisation of the normal human ganglion cell-inner plexiform layer using widefield optical coherence tomography.

Autor: Tong J; Centre for Eye Health, University of New South Wales, Sydney, New South Wales, Australia.; School of Optometry and Vision Science, University of New South Wales, Sydney, New South Wales, Australia., Alonso-Caneiro D; School of Science, Technology and Engineering, University of Sunshine Coast, Sunshine Coast, Queensland, Australia.; Contact Lens and Visual Optics Laboratory, Centre for Vision and Eye Research, School of Optometry and Vision Science, Queensland University of Technology, Kelvin Grove, Queensland, Australia., Kugelman J; Contact Lens and Visual Optics Laboratory, Centre for Vision and Eye Research, School of Optometry and Vision Science, Queensland University of Technology, Kelvin Grove, Queensland, Australia., Phu J; Centre for Eye Health, University of New South Wales, Sydney, New South Wales, Australia.; School of Optometry and Vision Science, University of New South Wales, Sydney, New South Wales, Australia.; Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia.; Concord Clinical School, Concord Repatriation General Hospital, Sydney, New South Wales, Australia.; School of Medicine (Optometry), Deakin University, Waurn Ponds, Victoria, Australia., Khuu SK; School of Optometry and Vision Science, University of New South Wales, Sydney, New South Wales, Australia., Kalloniatis M; School of Optometry and Vision Science, University of New South Wales, Sydney, New South Wales, Australia.; School of Medicine (Optometry), Deakin University, Waurn Ponds, Victoria, Australia.
Jazyk: angličtina
Zdroj: Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) [Ophthalmic Physiol Opt] 2024 Mar; Vol. 44 (2), pp. 457-471. Date of Electronic Publication: 2023 Nov 22.
DOI: 10.1111/opo.13255
Abstrakt: Purpose: To describe variations in ganglion cell-inner plexiform layer (GCIPL) thickness in a healthy cohort from widefield optical coherence tomography (OCT) scans.
Methods: Widefield OCT scans spanning 55° × 45° were acquired from 470 healthy eyes. The GCIPL was automatically segmented using deep learning methods. Thickness measurements were extracted after correction for warpage and retinal tilt. Multiple linear regression analysis was applied to discern trends between global GCIPL thickness and age, axial length and sex. To further characterise age-related change, hierarchical and two-step cluster algorithms were applied to identify locations sharing similar ageing properties, and rates of change were quantified using regression analyses with data pooled by cluster analysis outcomes.
Results: Declines in widefield GCIPL thickness with age, increasing axial length and female sex were observed (parameter estimates -0.053, -0.436 and -0.464, p-values <0.001, <0.001 and 0.02, respectively). Cluster analyses revealed concentric, slightly nasally displaced, horseshoe patterns of age-related change in the GCIPL, with up to four statistically distinct clusters outside the macula. Linear regression analyses revealed significant ageing decline in GCIPL thickness across all clusters, with faster rates of change observed at central locations when expressed as absolute (slope = -0.19 centrally vs. -0.04 to -0.12 peripherally) and percentage rates of change (slope = -0.001 centrally vs. -0.0005 peripherally).
Conclusions: Normative variations in GCIPL thickness from widefield OCT with age, axial length and sex were noted, highlighting factors worth considering in further developments. Widefield OCT has promising potential to facilitate quantitative detection of abnormal GCIPL outside standard fields of view.
(© 2023 The Authors. Ophthalmic and Physiological Optics published by John Wiley & Sons Ltd on behalf of College of Optometrists.)
Databáze: MEDLINE
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