The 10-year follow-up of a community-based cohort of people with diabetes: The incidence of foot ulceration and death.

Autor: Mohammed SA; School of Mathematics and Statistics, University of St Andrews, St Andrews, UK., Crawford F; School of Health and Social Care, University of Essex, Colchester, UK., Cezard GI; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK., Papathomas M; School of Mathematics and Statistics, University of St Andrews, St Andrews, UK.
Jazyk: angličtina
Zdroj: Endocrinology, diabetes & metabolism [Endocrinol Diabetes Metab] 2024 Jan; Vol. 7 (1), pp. e459. Date of Electronic Publication: 2023 Nov 21.
DOI: 10.1002/edm2.459
Abstrakt: Background: Identifying people with diabetes who are likely to experience a foot ulcer is an important part of preventative care. Many cohort studies report predictive models for foot ulcerations and for people with diabetes, but reports of long-term outcomes are scarce.
Aim: We aimed to develop a predictive model for foot ulceration in diabetes using a range of potential risk factors with a follow-up of 10 years after recruitment. A new foot ulceration was the outcome of interest and death was the secondary outcome of interest.
Design: A 10-year follow-up cohort study.
Methods: 1193 people with a diagnosis of diabetes who took part in a study in 2006-2007 were invited to participate in a 10-year follow-up. We developed a prognostic model for the incidence of incident foot ulcerations using a survival analysis, Cox proportional hazards model. We also utilised survival analysis Kaplan-Meier curves, and relevant tests, to assess the association between the predictor variables for foot ulceration and death.
Results: At 10-year follow-up, 41% of the original study population had died and more than 18% had developed a foot ulcer. The predictive factors for foot ulceration were an inability to feel a 10 g monofilament or vibration from a tuning fork, previous foot ulceration and duration of diabetes.
Conclusions: The prognostic model shows an increased risk of ulceration for those with previous history of foot ulcerations, insensitivity to a 10 g monofilament, a tuning fork and duration of diabetes. The incidence of foot ulceration at 10-year follow-up was 18%; however, the risk of death for this community-based population was far greater than the risk of foot ulceration.
(© 2023 The Authors. Endocrinology, Diabetes & Metabolism published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
Externí odkaz: