Whole-body bone mineral density and markers of bone homeostasis in adults with normal-weight obesity.
| Autor: | Keirns BH; Department of Nutritional Sciences, Oklahoma State University 301 Nancy Randolph Davis, Stillwater, OK, 74078, USA., Sciarrillo CM; Department of Nutritional Sciences, Oklahoma State University 301 Nancy Randolph Davis, Stillwater, OK, 74078, USA., Medlin AR; Department of Health & Wellness Design, Indiana University School of Public Health, 1025 E. Seventh St., Bloomington, IN, 47405, USA., Hart SM; Department of Nutritional Sciences, Oklahoma State University 301 Nancy Randolph Davis, Stillwater, OK, 74078, USA., Cronic EM; Department of Nutritional Sciences, Oklahoma State University 301 Nancy Randolph Davis, Stillwater, OK, 74078, USA., Emerson SR; Department of Nutritional Sciences, Oklahoma State University 301 Nancy Randolph Davis, Stillwater, OK, 74078, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Obesity Pillars (Online) [Obes Pillars] 2023 Jun 01; Vol. 7, pp. 100073. Date of Electronic Publication: 2023 Jun 01 (Print Publication: 2023). |
| DOI: | 10.1016/j.obpill.2023.100073 |
| Abstrakt: | Background: Normal-weight obesity (NWO) describes individuals with a normal body mass index (BMI), but high body fat percent. NWO are at-risk for cardiometabolic diseases, but little is known about their bone health. Methods: Adults (N = 24) were classified as NWO (n = 12; 5M/7F) or low body fat percent controls (Con; n = 12; 6M/6F). Body composition and whole-body bone mineral density (BMD) were assessed using DXA. A serum bioplex assay was performed to examine markers related to bone formation and resorption. Results: In addition to higher body fat percent and visceral fat, NWO had lower whole-body BMD relative to Con ( p 's < 0.05). Circulating leptin was higher in NWO than Con ( p < 0.05). Two biomarkers generally associated with lower bone mass - sclerostin and parathyroid hormone - were higher in NWO compared to Con ( p 's < 0.05). Conclusion: In this preliminary study, adults with NWO displayed lower whole-body BMD alongside evidence of bone resorption. Impaired bone health may be another subclinical risk factor present in NWO. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2023 The Authors.) |
| Databáze: | MEDLINE |
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