[Expression and significance of jumonji domain-containing protein 2B and hypoxia inducible factor-1α in non-Hodgkin lymphoma tissues in children].

Autor: Diao YQ; Department of Pediatrics, Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China., Wang J; Department of Pediatrics, Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China., Zhu XL; Department of Pediatrics, Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China., Chen J; Department of Pediatrics, Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China., Zheng Y; Department of Pediatrics, Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China., Jiang L; Department of Pediatrics, Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China., Liu YP, Dai RH; Department of Pediatrics, Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China., Yan YW; Department of Pediatrics, Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China.
Jazyk: čínština
Zdroj: Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics [Zhongguo Dang Dai Er Ke Za Zhi] 2023 Nov 15; Vol. 25 (11), pp. 1150-1155.
DOI: 10.7499/j.issn.1008-8830.2305025
Abstrakt: Objectives: To investigate the expression and significance of jumonji domain-containing protein 2B (JMJD2B) and hypoxia-inducible factor-1α (HIF-1α) in non-Hodgkin's lymphoma (NHL) tissues in children.
Methods: Immunohistochemistry was used to detect the expression of JMJD2B and HIF-1α in lymph node tissue specimens from 46 children with NHL (observation group) and 24 children with reactive hyperplasia (control group). The relationship between JMJD2B and HIF-1α expression with clinicopathological characteristics and prognosis in children with NHL, as well as the correlation between JMJD2B and HIF-1α expression in NHL tissues, were analyzed.
Results: The positive expression rates of JMJD2B (87% vs 21%) and HIF-1α (83% vs 42%) in the observation group were higher than those in the control group ( P <0.05). The expression of JMJD2B and HIF-1α was correlated with serum lactate dehydrogenase levels and the risk of international prognostic index in children with NHL ( P <0.05). The expression of JMJD2B was positively correlated with the HIF-1α expression in children with NHL ( r s =0.333, P =0.024).
Conclusions: JMJD2B and HIF-1α are upregulated in children with NHL, and they may play a synergistic role in the development of pediatric NHL. JMJD2B can serve as a novel indicator for auxiliary diagnosis, evaluation of the severity, treatment guidance, and prognosis assessment in pediatric NHL.
Databáze: MEDLINE
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