Impact of Deceased-donor Acute Kidney Injury on Kidney Transplantation.

Autor:	Yaffe HC; Montefiore Einstein Center for Transplantation, Department of Surgery, Montefiore Medical Center, Bronx, NY.; Albert Einstein College of Medicine, Bronx, NY., von Ahrens D; Montefiore Einstein Center for Transplantation, Department of Surgery, Montefiore Medical Center, Bronx, NY.; Albert Einstein College of Medicine, Bronx, NY., Urioste A; Surgical Sciences Division, University of Maryland School of Medicine, Baltimore, MD., Mas VR; Surgical Sciences Division, University of Maryland School of Medicine, Baltimore, MD., Akalin E; Albert Einstein College of Medicine, Bronx, NY.; Montefiore Einstein Center for Transplantation, Department of Medicine, Montefiore Medical Center, Bronx, NY.
Jazyk:	angličtina
Zdroj:	Transplantation [Transplantation] 2024 Jun 01; Vol. 108 (6), pp. 1283-1295. Date of Electronic Publication: 2023 Nov 22.
DOI:	10.1097/TP.0000000000004848
Abstrakt:	Even as record numbers of deceased donors are undergoing organ recovery, the global transplant community continues to struggle with a shortage of donor organs and a high organ discard rate. Acute kidney injury (AKI) occurs in many hospitalized patients, including up to 25% of patients in critical condition. Registry studies have shown a significant increase in nonrecovery or organ discard rates in AKI donors, despite most studies reporting similar clinical outcomes compared with non-AKI donors. This review aims to capture the salient information learned from these studies and to summarize the efforts that have been made to gain a more granular understanding of how kidneys from donors with AKI behave posttransplant. In particular, we reviewed the studies that analyzed the clinical outcomes in different stages of AKI and AKI in marginal donors, such as kidney donor profile index of >85%, older donors, and donation after circulatory death donors. We summarized studies investigating molecular biomarkers, transcriptomics, and possible future therapeutic targets for postdonation AKI. Competing Interests: The authors declare no conflicts of interest. (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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