ARFID Genes and Environment (ARFID-GEN): study protocol.

Autor: Bulik CM; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. cynthia_bulik@med.unc.edu.; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, 171 77, Stockholm, Sweden. cynthia_bulik@med.unc.edu.; Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, US. cynthia_bulik@med.unc.edu., Micali N; Center for Eating and Feeding Disorders Research, Psychiatric Center Ballerup, Mental Health Services of the Capital Region of Denmark, Ballerup, Denmark.; Institute of Biological Psychiatry, Psykiatrisk Center Sct. Hans, Boserupvej 2, 4000, Roskilde, Denmark.; Great Ormond Street Hospital Institute of Child Health, University College London, London, UK., MacDermod CM; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA., Qi B; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27516, USA., Munn-Chernoff MA; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.; Texas Tech University, Lubbock, TX, 79409, USA., Thornton LM; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA., White J; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA., Dinkler L; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, 171 77, Stockholm, Sweden., Pisetsky EM; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA., Johnson J; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA., Devine KR; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA., Ortiz SN; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA., Silverman AE; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.; Smith College, Northampton, MA, 01063, USA., Berthold N; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.; University of Western Australia, Crawley, WA, 6009, Australia.; Perron Institute for Neurological and Translational Science, Nedlands, WA, 6009, Australia., Dumain A; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.; Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, US., Guintivano J; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA., Halvorsen M; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden., Crowley JJ; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Jazyk: angličtina
Zdroj: BMC psychiatry [BMC Psychiatry] 2023 Nov 21; Vol. 23 (1), pp. 863. Date of Electronic Publication: 2023 Nov 21.
DOI: 10.1186/s12888-023-05266-x
Abstrakt: Background: The Avoidant Restrictive Food Intake Disorder - Genes and Environment (ARFID-GEN) study is a study of genetic and environmental factors that contribute to risk for developing ARFID in children and adults.
Methods: A total of 3,000 children and adults with ARFID from the United States will be included. Parents/guardians and their children with ARFID (ages 7 to 17) and adults with ARFID (ages 18 +) will complete comprehensive online consent, parent verification of child assent (when applicable), and phenotyping. Enrolled participants with ARFID will submit a saliva sample for genotyping. A genome-wide association study of ARFID will be conducted.
Discussion: ARFID-GEN, a large-scale genetic study of ARFID, is designed to rapidly advance the study of the genetics of eating disorders. We will explicate the genetic architecture of ARFID relative to other eating disorders and to other psychiatric, neurodevelopmental, and metabolic disorders and traits. Our goal is for ARFID to deliver "actionable" findings that can be transformed into clinically meaningful insights.
Trial Registration: ARFID-GEN is a registered clinical trial: clinicaltrials.gov NCT05605067.
(© 2023. The Author(s).)
Databáze: MEDLINE
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