Transposon wave remodeled the epigenomic landscape in the rapid evolution of X-Chromosome dosage compensation.

Autor:	Metzger DCH; Department of Zoology and Biodiversity Research Centre, University of British Columbia, Vancouver, British Columbia, V6T 1Z4, Canada; dmetzger@zoology.ubc.ca., Porter I; Department of Zoology and Biodiversity Research Centre, University of British Columbia, Vancouver, British Columbia, V6T 1Z4, Canada., Mobley B; Biology Department, Reed College, Portland, Oregon 97202, USA., Sandkam BA; Department of Neurobiology and Behavior, Cornell University, Ithaca, New York 14853, USA., Fong LJM; Department of Zoology and Biodiversity Research Centre, University of British Columbia, Vancouver, British Columbia, V6T 1Z4, Canada., Anderson AP; Biology Department, Reed College, Portland, Oregon 97202, USA., Mank JE; Department of Zoology and Biodiversity Research Centre, University of British Columbia, Vancouver, British Columbia, V6T 1Z4, Canada.
Jazyk:	angličtina
Zdroj:	Genome research [Genome Res] 2023 Dec 01; Vol. 33 (11), pp. 1917-1931. Date of Electronic Publication: 2023 Dec 01.
DOI:	10.1101/gr.278127.123
Abstrakt:	Sex chromosome dosage compensation is a model to understand the coordinated evolution of transcription; however, the advanced age of the sex chromosomes in model systems makes it difficult to study how the complex regulatory mechanisms underlying chromosome-wide dosage compensation can evolve. The sex chromosomes of Poecilia picta have undergone recent and rapid divergence, resulting in widespread gene loss on the male Y, coupled with complete X Chromosome dosage compensation, the first case reported in a fish. The recent de novo origin of dosage compensation presents a unique opportunity to understand the genetic and evolutionary basis of coordinated chromosomal gene regulation. By combining a new chromosome-level assembly of P. picta with whole-genome bisulfite sequencing and RNA-seq data, we determine that the YY1 transcription factor (YY1) DNA binding motif is associated with male-specific hypomethylated regions on the X, but not the autosomes. These YY1 motifs are the result of a recent and rapid repetitive element expansion on the P. picta X Chromosome, which is absent in closely related species that lack dosage compensation. Taken together, our results present compelling support that a disruptive wave of repetitive element insertions carrying YY1 motifs resulted in the remodeling of the X Chromosome epigenomic landscape and the rapid de novo origin of a dosage compensation system. (© 2023 Metzger et al.; Published by Cold Spring Harbor Laboratory Press.)
Databáze:	MEDLINE
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