Severe viral lower respiratory tract infections in Brazilian children: Clinical features of a national cohort.

Autor:	Menezes RC; Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER Initiative), Brazil; Instituto de Pesquisa Clínica e Translacional (IPCT), UniFTC, Bahia, Brazil; Universidade Federal da Bahia (UFBA), Bahia, Brazil; Fundação Oswaldo Cruz (FIOCRUZ), Bahia, Brazil., Ferreira IBB; Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER Initiative), Brazil; Instituto de Pesquisa Clínica e Translacional (IPCT), UniFTC, Bahia, Brazil; Escola Bahiana de Medicina e Saúde Pública (EBMSP), Bahia, Brazil., Sobral L; Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER Initiative), Brazil; Instituto de Pesquisa Clínica e Translacional (IPCT), UniFTC, Bahia, Brazil; Escola Bahiana de Medicina e Saúde Pública (EBMSP), Bahia, Brazil., Garcia SL; Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER Initiative), Brazil; Universidade Salvador, Bahia, Brazil., Pustilnik HN; Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER Initiative), Brazil; Universidade Salvador, Bahia, Brazil., Araújo-Pereira M; Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER Initiative), Brazil; Instituto de Pesquisa Clínica e Translacional (IPCT), UniFTC, Bahia, Brazil; Universidade Federal da Bahia (UFBA), Bahia, Brazil; Fundação Oswaldo Cruz (FIOCRUZ), Bahia, Brazil., Andrade BB; Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER Initiative), Brazil; Instituto de Pesquisa Clínica e Translacional (IPCT), UniFTC, Bahia, Brazil; Universidade Federal da Bahia (UFBA), Bahia, Brazil; Fundação Oswaldo Cruz (FIOCRUZ), Bahia, Brazil; Universidade Salvador, Bahia, Brazil. Electronic address: bruno.andrade@fiocruz.br.
Jazyk:	angličtina
Zdroj:	Journal of infection and public health [J Infect Public Health] 2024 Jan; Vol. 17 (1), pp. 1-9. Date of Electronic Publication: 2023 Sep 30.
DOI:	10.1016/j.jiph.2023.09.015
Abstrakt:	Background: The accurate etiological diagnosis of lower respiratory tract infections (LRTI) is essential for their effective clinical management. The extensive use of molecular methods during the COVID-19 pandemic has enabled massive data acquisition on viral lower respiratory tract infections. The current study aims to identify clinical features associated with eight viral agents among children presenting severe LRTI. Methods: retrospective cohort study of data from the Brazilian Influenza Epidemiological Surveillance Information System. Patients under 20 years-old who had severe LRTI with etiological confirmation through RT-PCR between 2020 and 2022 were included. Binary logistic regressions were used to examine associations between pathogens and symptoms. Results: 60,657 cases were assessed. The main viral agents detected were Sars-CoV-2 (COV2) (41.2%), Respiratory Syncytial Virus (29.1%), Human Rhinovirus (HRV) (12.1%), and Influenza (FLU) (5.5%). A general mortality rate of 4.3% was observed. The multivariate analysis evidenced that COV2 less likely presented with cough (OR: 0.34; 95%CI: 0.32-0.36), respiratory discomfort (Adjusted Odds Ratio (aOR): 0.61; 95%Confidence Interval (CI): 0.59-0.64), and desaturation (aOR: 0.71; 95%CI: 0.69-0.75). RSV strongly associated with cough (aOR: 2.59; 95%CI: 2.45-2.75) and respiratory discomfort (aOR: 1.54; 95%CI: 1.46-1.62), whereas FLU was linked to fever (aOR: 2.27; 95%CI: 2.06-2.50) and sore throat (aOR: 1.48; 95%CI: 1.34-1.64). Conclusions: The viral agents responsible for severe LRTI have distinct associations with clinical features in children. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze:	MEDLINE
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