Effect of Glutamate Antibody F(ab)2 Fragments on Memory Changes in Aged C57BL/6 Mice.

Autor: Davydova TV; Research Institute of General Pathology and Pathophysiology, Moscow, Russia. dav-ta@yandex.ru., Vetrile LA; Research Institute of General Pathology and Pathophysiology, Moscow, Russia., Zakharova IA; Research Institute of General Pathology and Pathophysiology, Moscow, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2023 Oct; Vol. 175 (6), pp. 762-764. Date of Electronic Publication: 2023 Nov 21.
DOI: 10.1007/s10517-023-05941-9
Abstrakt: Intranasal administration of F(ab)2 fragments of anti-glutamate antibodies to 12-month-old C57BL/6 mice improves passive avoidance conditioning and have no effect on horizontal and vertical locomotor activity in the open-field test. In contrast to full-length antibodies to glutamate, their F(ab)2 fragments significantly increase the number of animals developed a conditioned passive avoidance reflex.
(© 2023. Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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