Safety Evaluation of a Prototypical Diazirine-Based Covalent Crosslinker and Molecular Adhesive.
| Autor: | Baran MJ; XLYNX Materials Inc., Victoria, BC, Canada., Hof R; Department of Chemistry, University of Victoria, Victoria, BC, Canada.; Centre for Advanced Materials and Related Technology (CAMTEC), University of Victoria, Victoria, BC, Canada., Groot A; Charles River Laboratories Den Bosch BV, 's-Hertogenbosch, The Netherlands., Eurlings I; Charles River Laboratories Den Bosch BV, 's-Hertogenbosch, The Netherlands., Gijsbrechts J; Charles River Laboratories Den Bosch BV, 's-Hertogenbosch, The Netherlands., de Jong B; Charles River Laboratories Den Bosch BV, 's-Hertogenbosch, The Netherlands., Wulff JE; Department of Chemistry, University of Victoria, Victoria, BC, Canada.; Centre for Advanced Materials and Related Technology (CAMTEC), University of Victoria, Victoria, BC, Canada. |
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| Jazyk: | angličtina |
| Zdroj: | International journal of toxicology [Int J Toxicol] 2024 Mar-Apr; Vol. 43 (2), pp. 146-156. Date of Electronic Publication: 2023 Nov 21. |
| DOI: | 10.1177/10915818231215692 |
| Abstrakt: | bis -Diazirine reagents are increasingly being used as polymer crosslinkers, adhesives, and photopatterning agents in the materials sciences literature, but little effort has been made thus far to document their chemical safety profile. Here, we describe the results of a detailed toxicity assessment of a representative bis -diazirine. Safety was evaluated by a series of in vitro assays, which found the product to be non-mutagenic in bacterial tester strains TA98 and TA100, non-corrosive and non-irritating to skin, and requiring no classification for eye irritation or serious damage. While in vitro tests do not capture the integrated whole animal system, and thus cannot completely rule out the possibility of adverse responses, the results of this study suggest a desirable safety profile for bis -diazirine reagents and provide a solid foundation upon which to add in vivo assessment of safety risk and dose-response studies. Competing Interests: Declaration of Conflicting InterestsThe author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: J.W. is a co-author on patent WO/2021/179064, which claims the use of BondLynx, and which is assigned to XLYNX Materials. M.B. is an employee of XLYNX Materials. |
| Databáze: | MEDLINE |
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