Highly Pathogenic Avian Influenza A(H5N1) Virus Clade 2.3.4.4b Infections in Wild Terrestrial Mammals, United States, 2022.

Autor: Elsmo EJ, Wünschmann A, Beckmen KB, Broughton-Neiswanger LE, Buckles EL, Ellis J, Fitzgerald SD, Gerlach R, Hawkins S, Ip HS, Lankton JS, Lemley EM, Lenoch JB, Killian ML, Lantz K, Long L, Maes R, Mainenti M, Melotti J, Moriarty ME, Nakagun S, Ruden RM, Shearn-Bochsler V, Thompson D, Torchetti MK, Van Wettere AJ, Wise AG, Lim AL
Jazyk: angličtina
Zdroj: Emerging infectious diseases [Emerg Infect Dis] 2023 Dec; Vol. 29 (12), pp. 2451-2460.
DOI: 10.3201/eid2912.230464
Abstrakt: We describe the pathology of natural infection with highly pathogenic avian influenza A(H5N1) virus of Eurasian lineage Goose/Guangdong clade 2.3.4.4b in 67 wild terrestrial mammals throughout the United States during April 1‒July 21, 2022. Affected mammals include 50 red foxes (Vulpes vulpes), 6 striped skunks (Mephitis mephitis), 4 raccoons (Procyon lotor), 2 bobcats (Lynx rufus), 2 Virginia opossums (Didelphis virginiana), 1 coyote (Canis latrans), 1 fisher (Pekania pennanti), and 1 gray fox (Urocyon cinereoargenteus). Infected mammals showed primarily neurologic signs. Necrotizing meningoencephalitis, interstitial pneumonia, and myocardial necrosis were the most common lesions; however, species variations in lesion distribution were observed. Genotype analysis of sequences from 48 animals indicates that these cases represent spillover infections from wild birds.
Databáze: MEDLINE