MRI Quantification of Left Atrial Circumferential Strain in Mitral Regurgitation: A Feasibility and Reproducibility Study.

Autor: Sreedhar SP; Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Gupta A; Department of Radiology, Stanford University, Stanford, California, USA., Chitiboi T; Digital Technology and Innovation, Siemens Healthineers, Erlangen, Germany., Pradella M; Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Department of Radiology, Clinic of Radiology and Nuclear Medicine, University Hospital of Basel, Basel, Switzerland., Elbaz MSM; Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Jazyk: angličtina
Zdroj: Journal of magnetic resonance imaging : JMRI [J Magn Reson Imaging] 2024 Sep; Vol. 60 (3), pp. 988-998. Date of Electronic Publication: 2023 Nov 21.
DOI: 10.1002/jmri.29137
Abstrakt: Background: MRI-derived left atrial (LA) longitudinal strain has been shown to be a marker for mitral regurgitation, but the utility of LA circumferential strain remains unclear.
Purpose: To assess feasibility and reproducibility of LA circumferential strain, identify changes in mitral regurgitation patients compared to healthy volunteers, and determine strain's association with mitral regurgitation severity and cardiac function.
Study Type: Retrospective.
Population: 52 mitral regurgitation patients, 12 healthy volunteers.
Field Strength/sequence: Steady-state free precession cine and 2D phase contrast sequences at 1.5T.
Assessment: Peak LA circumferential strain was computed in each of three short-axis slices (superior, mid, and inferior) and longitudinal strain computed from long-axis slices using MRI feature-tracking software. Strain test-retest reproducibility was determined from two repeat studies in healthy volunteers.
Statistical Tests: LA circumferential strain test-retest reproducibility was assessed by intra-class correlation coefficient (ICC). Strain was compared between cohorts using Student's t-test or Mann-Whitney U. Mitral regurgitation severity association with strain and LV function was assessed using Spearman correlation and multivariable regression. Significance was defined as P < 0.05.
Results: LA circumferential strain assessment was feasible in all subjects with moderate reproducibility in the superior (ICC = 0.74), mid LA (ICC = 0.71), and inferior LA (ICC = 0.63). In mitral regurgitation patients, LA circumferential strain was significantly lower in the superior (11.86% [6.5%,19.2%] vs. 18.73% ± 6.7%) and mid LA slices (18.41% ± 9.5% vs. 28.7% ± 10.4%) compared to healthy volunteers. Mitral regurgitation severity significantly associated with mid LA circumferential strain (β = -0.03) and LAV significantly associated with superior LA circumferential strain (β = -2.09), both independent of LA longitudinal strain and CO.
Data Conclusion: LA circumferential strain assessment is feasible with moderate reproducibility. Compared to healthy volunteers, patients had significantly lower LA circumferential strain. Mitral regurgitation severity and LAV were significantly associated with LA circumferential strain independent of LA longitudinal strain.
Evidence Level: 3 TECHNICAL EFFICACY: Stage 2.
(© 2023 The Authors. Journal of Magnetic Resonance Imaging published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.)
Databáze: MEDLINE
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