Radiotranscriptomics identified new mRNAs and miRNA markers for distinguishing prostate cancer from benign prostatic hyperplasia.

Autor: Yang Q; Department of Ultrasound, Air Force Medical Center, PLA, Air Force Military Medical University, Beijing, China.; Department of Ultrasound, First Medical Center, Chinese PLA General Hospital, Beijing, China., Li Q; Department of Ultrasound, First Medical Center, Chinese PLA General Hospital, Beijing, China., Li N; Department of Ultrasound, First Medical Center, Chinese PLA General Hospital, Beijing, China., Wang D; Department of Ultrasound, First Medical Center, Chinese PLA General Hospital, Beijing, China., Niu S; Department of Urology, First Medical Center, Chinese PLA General Hospital, Beijing, China., Tang P; Department of Orthopedics, China Rehabilitation Research Center, Beijing Charity Hospital, Beijing, China., Xiao J; Department of Ultrasound, First Medical Center, Chinese PLA General Hospital, Beijing, China., Zhao J; Department of Ultrasound, First Medical Center, Chinese PLA General Hospital, Beijing, China., Wang P; Department of Ultrasound Diagnosis and Treatment Center, Xi'an International Medical Center Hospital, Xian, China., Luo Y; Department of Ultrasound, Air Force Medical Center, PLA, Air Force Military Medical University, Beijing, China.; Department of Ultrasound, First Medical Center, Chinese PLA General Hospital, Beijing, China., Tang J; Department of Ultrasound, First Medical Center, Chinese PLA General Hospital, Beijing, China.
Jazyk: angličtina
Zdroj: Cancer medicine [Cancer Med] 2023 Dec; Vol. 12 (24), pp. 21694-21708. Date of Electronic Publication: 2023 Nov 21.
DOI: 10.1002/cam4.6728
Abstrakt: The present study investigated ultrasound (US) phenotypes reflecting prostate cancer (PCa)-related genetic mutations. Herein, integration of radiotranscriptomic data, US and contrast-enhanced ultrasound (CEUS) radiomic images, and RNA sequencing was performed with the aim of significantly improving the accuracy of PCa prognosis. We performed radiotranscriptomic analysis of clinical, imaging, and two genomic (mRNA and microRNA expression) datasets from 48 and 22 men with PCa and benign prostatic hyperplasia (BPH), respectively. Twenty-three US texture features and four microvascular perfusion features were associated with various patterns of 52 differentially expressed genes related to PCa (p < 0.05); 17 overexpressed genes were associated with two key texture features. Twelve overexpressed genes were identified using microvascular perfusion features. Furthermore, mRNA and miRNA biomarkers could be used to distinguish between PCa and BPH. Compared with RNA sequencing, B-mode and CEUS features reflected genomic alterations associated with hormone receptor status, angiogenesis, and prognosis in patients with PCa. These findings indicate the potential of US to assess biomarker levels in patients with PCa.
(© 2023 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje