Functional parcellation of the neonatal brain.

Autor:	Myers MJ; Department of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA., Labonte AK; Department of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA.; Neurosciences Graduate Program, Washington University in St. Louis, St. Louis, MO USA., Gordon EM; Department of Radiology, Washington University in St. Louis, St. Louis, MO USA., Laumann TO; Department of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA., Tu JC; Neurosciences Graduate Program, Washington University in St. Louis, St. Louis, MO USA.; Department of Radiology, Washington University in St. Louis, St. Louis, MO USA., Wheelock MD; Department of Radiology, Washington University in St. Louis, St. Louis, MO USA., Nielsen AN; Department of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA., Schwarzlose R; Department of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA., Camacho MC; Department of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA., Warner BB; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA., Raghuraman N; Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO, USA., Luby JL; Department of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA., Barch DM; Department of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA.; Department of Psychological & Brain Sciences, Washington University in St. Louis, St. Louis, MO, USA., Fair DA; Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA.; Institute of Child Development, University of Minnesota, Minneapolis, MN, USA.; Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA., Petersen SE; Department of Radiology, Washington University in St. Louis, St. Louis, MO USA.; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., Rogers CE; Department of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA., Smyser CD; Department of Radiology, Washington University in St. Louis, St. Louis, MO USA.; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., Sylvester CM; Department of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA.; Department of Radiology, Washington University in St. Louis, St. Louis, MO USA.; Taylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine, St. Louis, MO, USA.
Jazyk:	angličtina
Zdroj:	BioRxiv : the preprint server for biology [bioRxiv] 2023 Nov 11. Date of Electronic Publication: 2023 Nov 11.
DOI:	10.1101/2023.11.10.566629
Abstrakt:	The cerebral cortex is organized into distinct but interconnected cortical areas, which can be defined by abrupt differences in patterns of resting state functional connectivity (FC) across the cortical surface. Such parcellations of the cortex have been derived in adults and older infants, but there is no widely used surface parcellation available for the neonatal brain. Here, we first demonstrate that adult- and older infant-derived parcels are a poor fit with neonatal data, emphasizing the need for neonatal-specific parcels. We next derive a set of 283 cortical surface parcels from a sample of n=261 neonates. These parcels have highly homogenous FC patterns and are validated using three external neonatal datasets. The Infomap algorithm is used to assign functional network identities to each parcel, and derived networks are consistent with prior work in neonates. The proposed parcellation may represent neonatal cortical areas and provides a powerful tool for neonatal neuroimaging studies. Competing Interests: COMPETING INTERESTS Damien A. Fair is a patent holder on the Framewise Integrated Real-Time Motion Monitoring (FIRMM) software. He is also a co-founder of Turing Medical Inc. that licenses this software. The nature of this financial interest and the design of the study have been reviewed by the University of Minnesota, and a plan has been established to ensure that this research study is not affected by the financial interest. The other authors declare no competing interests.
Databáze:	MEDLINE
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