Interpenetrating alginate network as drug delivery matrix: Effects on protein stability and release.

Autor: Monteiro APF; Interfaculty Research Center of Biomaterials (CEIB), University of Liège, Liège, Belgium.; Department of Chemical Engineering - Nanomaterials, Catalysis and Electrochemistry (NCE), University of Liège, Liège, Belgium., Pérez-Jiménez A; Interfaculty Research Center of Biomaterials (CEIB), University of Liège, Liège, Belgium., Spitzlei C; Interfaculty Research Center of Biomaterials (CEIB), University of Liège, Liège, Belgium., Caucheteux J; Interfaculty Research Center of Biomaterials (CEIB), University of Liège, Liège, Belgium., Alves VD; LEAF-Linking Landscape Environment Agriculture and Food Research Center, Associate Laboratory TERRA, Instituto Superior de Agronomia, University of Lisbon, Lisbon, Portugal., Lambert S; Department of Chemical Engineering - Nanomaterials, Catalysis and Electrochemistry (NCE), University of Liège, Liège, Belgium., Grandfils C; Interfaculty Research Center of Biomaterials (CEIB), University of Liège, Liège, Belgium.
Jazyk: angličtina
Zdroj: Journal of biomedical materials research. Part B, Applied biomaterials [J Biomed Mater Res B Appl Biomater] 2024 Jan; Vol. 112 (1), pp. e35354. Date of Electronic Publication: 2023 Nov 20.
DOI: 10.1002/jbm.b.35354
Abstrakt: The study investigates the rheological properties and protein release capacity of a uniform hydrogel composed of sodium alginate (SA) and poloxamer (P407). The hydrogel is prepared through the sustained release of calcium ions, resulting in a reinforced and homogeneous interpenetrating networks (IPNs) of SA and P407 polymeric chains. By adjusting the amount of crosslink agent, the hydrogel exhibites an adjustable dissolution ratio and adaptable gelling time. Moreover, the composite showed a well-structured network and superior mechanical strength, enabling the sustained release of both calcium ions and Soybean Trypsin Inhibitor (STI) protein, a model of Bone Morphogenic Protein (BMP). Importantly, the protein release kinetic can be tuned based on the SA content in the polymeric blend, highlighting the versatile nature of this hydrogel for drug delivery purposes.
(© 2023 Wiley Periodicals LLC.)
Databáze: MEDLINE
Externí odkaz: