Too big not to fail: emerging evidence for size-induced senescence.

Autor: Manohar S; Department of Biology, Institute for Biochemistry, ETH Zürich, Switzerland., Neurohr GE; Department of Biology, Institute for Biochemistry, ETH Zürich, Switzerland.
Jazyk: angličtina
Zdroj: The FEBS journal [FEBS J] 2024 Jun; Vol. 291 (11), pp. 2291-2305. Date of Electronic Publication: 2023 Nov 20.
DOI: 10.1111/febs.16983
Abstrakt: Cellular senescence refers to a permanent and stable state of cell cycle exit. This process plays an important role in many cellular functions, including tumor suppression. It was first noted that senescence is associated with increased cell size in the early 1960s; however, how this contributes to permanent cell cycle exit was poorly understood until recently. In this review, we discuss new findings that identify increased cell size as not only a consequence but also a cause of permanent cell cycle exit. We highlight recent insights into how increased cell size alters normal cellular physiology and creates homeostatic imbalances that contribute to senescence induction. Finally, we focus on the potential clinical implications of these findings in the context of cell cycle arrest-causing cancer therapeutics and speculate on how tumor cell size changes may impact outcomes in patients treated with these drugs.
(© 2023 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.)
Databáze: MEDLINE
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