Associations of obesity and dengue-associated mortality, acute liver failure and mechanical ventilation in children with dengue shock syndrome.

Autor:	Nguyen TT; Department of Infectious Diseases, Children's Hospital No. 2, Ho Chi Minh City, Vietnam.; Woolcock Institute of Medical Research, Ho Chi Minh City, Vietnam.; Faculty of Medicine, Texila American University, Georgetown, Guyana., Nguyen DT; Department of Infectious Diseases, Children's Hospital No. 2, Ho Chi Minh City, Vietnam.; Faculty of Medicine, Texila American University, Georgetown, Guyana., Vo TT; Department of Infectious Diseases, Children's Hospital No. 2, Ho Chi Minh City, Vietnam., Dang OT; Department of Infectious Diseases, Children's Hospital No. 2, Ho Chi Minh City, Vietnam., Nguyen BT; Department of Infectious Diseases, Children's Hospital No. 2, Ho Chi Minh City, Vietnam., Pham DT; Department of Infectious Diseases, Children's Hospital No. 2, Ho Chi Minh City, Vietnam., Nguyen TT; Department of Infectious Diseases, Children's Hospital No. 2, Ho Chi Minh City, Vietnam., Duong YN; Department of Infectious Diseases, Children's Hospital No. 2, Ho Chi Minh City, Vietnam., Doan DH; Department of Infectious Diseases, Children's Hospital No. 2, Ho Chi Minh City, Vietnam., Nguyen TH; Department of Infectious Diseases, Children's Hospital No. 2, Ho Chi Minh City, Vietnam., Ho LT; Department of Infectious Diseases, Children's Hospital No. 2, Ho Chi Minh City, Vietnam., Nguyen PH; Department of Infectious Diseases, Children's Hospital No. 2, Ho Chi Minh City, Vietnam., Phan DN; Department of Infectious Diseases, Children's Hospital No. 2, Ho Chi Minh City, Vietnam., Tran TV; Department of Infectious Diseases, Children's Hospital No. 2, Ho Chi Minh City, Vietnam., Nguyen TK; Department of Infectious Diseases, Children's Hospital No. 2, Ho Chi Minh City, Vietnam., Luong DC; Department of Infectious Diseases, Children's Hospital No. 2, Ho Chi Minh City, Vietnam., Pham AT; Department of Infectious Diseases, Children's Hospital No. 2, Ho Chi Minh City, Vietnam., Dinh TT; Department of Infectious Diseases, Children's Hospital No. 2, Ho Chi Minh City, Vietnam., Do VC; Department of Infectious Diseases, Children's Hospital No. 2, Ho Chi Minh City, Vietnam., Vo LT; Department of Infectious Diseases, Children's Hospital No. 2, Ho Chi Minh City, Vietnam.
Jazyk:	angličtina
Zdroj:	Medicine [Medicine (Baltimore)] 2023 Nov 17; Vol. 102 (46), pp. e36054.
DOI:	10.1097/MD.0000000000036054
Abstrakt:	Dengue-associated complications, including dengue shock syndrome, severe respiratory distress, and pediatric acute liver failure (PALF), are associated with high mortality rates in patients with dengue. There is increasing prevalence of overweight and obesity among children worldwide. Obesity may activate inflammatory mediators, leading to increased capillary permeability and plasma leakage in patients with dengue. Several studies have shown a correlation between obesity and DSS, but did not include dengue fatality or PALF. Therefore, we hypothesized possible associations between obesity and critical dengue-associated clinical outcomes among PICU-admitted children with DSS, including dengue-related mortality, mechanical ventilation (MV) requirements, and dengue-associated PALF. The nutritional status of the participants was assessed using World Health Organization growth charts. A total of 858 participants with complete nutritional data were enrolled in this study. Obesity was significantly associated with risk of severe respiratory failure and MV support (odds ratio = 2.3, 95% CI: 1.31-4.06, P < .01); however, it was not associated with dengue-associated mortality or acute liver failure. Obese pediatric patients with DSS should be closely monitored for severe respiratory distress and the need for high-flow oxygenation support, particularly MV, soon after hospitalization. Competing Interests: The authors have no conflicts of interest to disclose. (Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.)
Databáze:	MEDLINE
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