Clinical profile of vitiligo patients and relationship with immuno-inflammatory markers.

Autor:	Mascarenhas MRM; Dermatology Service, Hospital Universitário Professor Edgard Santos, Salvador, BA, Brazil. Electronic address: martarpmachado@yahoo.com.br., Oliveira MC; Dermatology Service, Hospital Universitário Professor Edgard Santos, Salvador, BA, Brazil., Oliveira LF; Dermatology Service, Hospital Universitário Professor Edgard Santos, Salvador, BA, Brazil., Magalhães AS; Dermatology Service, Hospital Universitário Professor Edgard Santos, Salvador, BA, Brazil., Machado PRL; Dermatology Service, Hospital Universitário Professor Edgard Santos, Salvador, BA, Brazil.
Jazyk:	angličtina
Zdroj:	Anais brasileiros de dermatologia [An Bras Dermatol] 2024 Mar-Apr; Vol. 99 (2), pp. 196-201. Date of Electronic Publication: 2023 Nov 18.
DOI:	10.1016/j.abd.2023.03.007
Abstrakt:	Background: Vitiligo is the most common pigmentary disorder and is considered a chronic, cumulative, multifactorial disease. The crucial role of cytotoxic CD8+ T lymphocytes and the IFNγ/CXCL10 axis has been demonstrated in its pathogenesis. Objective: To evaluate the clinical profile and immuno-inflammatory markers in patients with vitiligo in a reference medical center. Methods: Cross-sectional study in which all patients with vitiligo seen at the medical center the from 2019 to 2022 were evaluated, to outline the clinical profile. Moreover, cardiovascular risk biomarkers (neutrophil/lymphocyte ratio and C-reactive protein levels) were measured, as well as cytokines and chemokines (TNFα, IFNγ, IL10, IL15 and CXCL10) in the serum of a subgroup of 30 patients. Results: There was a predominance of females, with a mean age of 43 years. Most were phototypes IV or V (71.3%), without comorbidities (77.55%), and without a family history of vitiligo (70.41%). Higher levels of neutrophil/lymphocyte ratio, C-reactive protein, and inflammatory cytokines/chemokines were documented in vitiligo patients when compared to the control group (non-significant). As relevant data, the highest values of CXCL10 were detected in patients with vitiligo versus controls, as well as in patients with disease of shorter duration (p<0.05). Study Limitations: The number of assessed patients was small due to recruitment difficulties caused by the COVID-19 pandemic. Conclusion: The present data contribute to confirming the relevant role of the IFNγ/CXCL10 axis in the pathogenesis of vitiligo, highlighting CXCL10 as a possible activity marker. (Copyright © 2023. Published by Elsevier España, S.L.U.)
Databáze:	MEDLINE
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