Antibodies internalization mechanisms by dendritic cells and their role in therapeutic antibody immunogenicity.

Autor: Lteif M; Université Paris-Saclay, Inserm, Inflammation, Microbiome and Immunosurveillance, Orsay, France., Pallardy M; Université Paris-Saclay, Inserm, Inflammation, Microbiome and Immunosurveillance, Orsay, France., Turbica I; Université Paris-Saclay, Inserm, Inflammation, Microbiome and Immunosurveillance, Orsay, France.
Jazyk: angličtina
Zdroj: European journal of immunology [Eur J Immunol] 2024 Feb; Vol. 54 (2), pp. e2250340. Date of Electronic Publication: 2023 Dec 03.
DOI: 10.1002/eji.202250340
Abstrakt: Internalization and processing by antigen-presenting cells such as dendritic cells (DCs) are critical steps for initiating a T-cell response to therapeutic antibodies. Consequences are the production of neutralizing antidrug antibodies altering the clinical response, the presence of immune complexes, and, in some rare cases, hypersensitivity reactions. In recent years, significant progress has been made in the knowledge of cellular uptake mechanisms of antibodies in DCs. The uptake of antibodies could be directly related to their immunogenicity by regulating the quantity of materials entering the DCs in relation to antibody structure. Here, we summarize the latest insights into cellular uptake mechanisms and pathways in DCs. We highlight the approaches to study endocytosis, the impact of endocytosis routes on T-cell response, and discuss the link between how DCs internalize therapeutic antibodies and the potential mechanisms that could give rise to immunogenicity. Understanding these processes could help in developing assays to evaluate the immunogenicity potential of biotherapeutics.
(© 2023 The Authors. European Journal of Immunology published by Wiley-VCH GmbH.)
Databáze: MEDLINE
Externí odkaz: