A geometry-based finite element tool for evaluating mitral valve biomechanics.

Autor: de Oliveira DC; Department of Mechanical Engineering, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom; Current affiliation: Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, United Kingdom. Electronic address: d.oliveira@ucl.ac.uk., Espino DM; Department of Mechanical Engineering, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom., Deorsola L; Paedriatic Cardiac Surgery, Ospedale Infantile Regina Margherita Sant Anna, Turin 10126, Italy., Buchan K; Department of Cardiothoracic Surgery, Aberdeen Royal Infirmary, Aberdeen AB24 2ZN, Scotland, UK., Dawson D; School of Medicine, University of Aberdeen, Aberdeen AB25 2ZD, Scotland, UK; Cardiology Department, Aberdeen Royal Infirmary, Aberdeen AB25 2ZN, Scotland, UK., Shepherd DET; Department of Mechanical Engineering, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.
Jazyk: angličtina
Zdroj: Medical engineering & physics [Med Eng Phys] 2023 Nov; Vol. 121, pp. 104067. Date of Electronic Publication: 2023 Oct 31.
DOI: 10.1016/j.medengphy.2023.104067
Abstrakt: Mitral valve function depends on its complex geometry and tissue health, with alterations in shape and tissue response affecting the long-term restorarion of function. Previous computational frameworks for biomechanical assessment are mostly based on patient-specific geometries; however, these are not flexible enough to yield a variety of models and assess mitral closure for individually tuned morphological parameters or material property representations. This study details the finite element approach implemented in our previously developed toolbox to assess mitral valve biomechanics and showcases its flexibility through the generation and biomechanical evaluation of different models. A healthy valve geometry was generated and its computational predictions for biomechanics validated against data in the literature. Moreover, two mitral valve models including geometric alterations associated with disease were generated and analysed. The healthy mitral valve model yielded biomechanical predictions in terms of valve closure dynamics, leaflet stresses and papillary muscle and chordae forces comparable to previous computational and experimental studies. Mitral valve function was compromised in geometries representing disease, expressed by the presence of regurgitating areas, elevated stress on the leaflets and unbalanced subvalvular apparatus forces. This showcases the flexibility of the toolbox concerning the generation of a range of mitral valve models with varying geometric definitions and material properties and the evaluation of their biomechanics.
Competing Interests: Declaration of Competing Interest There are no conflicts of interest to declare.
(Copyright © 2023 IPEM. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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