Early menarche and other endocrine disrupting effects of per- and polyfluoroalkyl substances (PFAS) in adolescents from Northern Norway. The Fit Futures study.

Autor: Averina M; Department of Laboratory Medicine, University Hospital of North Norway, Hansine Hansens veg 67, 9019, Tromsø, Norway; Department of Clinical Medicine, Endocrinological and Geriatric Research Group, UiT - The Arctic University of Norway, Hansine Hansens veg 18, 9019, Tromsø, Norway. Electronic address: maria.averina@unn.no., Huber S; Department of Laboratory Medicine, University Hospital of North Norway, Hansine Hansens veg 67, 9019, Tromsø, Norway., Almås B; Hormone Laboratory, Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Haukelandsveien 22, 5009, Bergen, Norway., Brox J; Department of Laboratory Medicine, University Hospital of North Norway, Hansine Hansens veg 67, 9019, Tromsø, Norway., Jacobsen BK; Department of Community Medicine, UiT The Arctic University of Norway, Hansine Hansens veg 18, 9019, Tromsø, Norway; Center for Sami Health Research, Department of Community Medicine, UiT The Arctic University of Norway, Hansine Hansens veg 18, 9019, Tromsø, Norway., Furberg AS; Department of Microbiology and Infection Control, University Hospital of North Norway, Hansine Hansens veg 67, 9019, Tromsø, Norway; Molde University College, Britvegen 2, 6410, Molde, Norway., Grimnes G; Department of Clinical Medicine, Endocrinological and Geriatric Research Group, UiT - The Arctic University of Norway, Hansine Hansens veg 18, 9019, Tromsø, Norway; Division of Medicine, University Hospital of North Norway, Hansine Hansens veg 67, 9019, Tromsø, Norway.
Jazyk: angličtina
Zdroj: Environmental research [Environ Res] 2024 Feb 01; Vol. 242, pp. 117703. Date of Electronic Publication: 2023 Nov 19.
DOI: 10.1016/j.envres.2023.117703
Abstrakt: Background: Per- and polyfluoroalkyl substances (PFAS) comprise a large group of chemicals that are ubiquitous in the environment and include recognized persistent organic pollutants. The aim of this cross-sectional study was to investigate possible endocrine disrupting effects of different PFAS in adolescents.
Methods: Serum concentrations of PFAS, thyroid, parathyroid and steroid hormones were measured in 921 adolescents aged 15-19 years in the Fit Futures study, Northern Norway. The questionnaire included data on self-reported age at menarche and puberty development score (PDS). Multiple linear and logistic regression analyses and principle component analyses (PCA) were used to assess associations of PFAS with hormones concentrations and puberty indices.
Results: In girls, total PFAS (∑PFAS), perfluorooctanoate (PFOA), perfluorooctane sulfonate (PFOS), perfluorononanoate (PFNA), perfluorodecanoate (PFDA) were positively associated with dehydroepiandrosterone sulfate (DHEAS) and negatively associated with 11-deoxycorticosterone (11-DOC)/DHEAS ratio. In boys, the associations with 11-DOC/DHEAS ratio were positive for ∑PFAS, perfluoroheptanoate (PFHpA), perfluoroheptane sulfonate (PFHpS), PFOA, and PFOS. Perfluoroundecanoate (PFUnDA) was negatively associated with free thyroxine (fT4) and free triiodothyronine (fT3) in boys. PFNA and PFDA were also negatively associated with fT3 in boys. Serum parathyroid hormone concentration (PTH) was negatively associated with ∑PFAS and perfluorohexane sulfonate (PFHxS) in girls, and with PFOS in boys. PFDA and PFUnDA were positively associated with early menarche, while ∑PFAS and PFOA were positively associated with PDS in boys. No associations of PFAS with serum testosterone, follicle-stimulating hormone, or luteinizing hormone were found in either sex. In girls, PFOA was positively associated with free testosterone index (FTI). In boys, PFOA was positively associated with androstendione and 17-OH-progesterone, while PFHpA was positively associated with estradiol.
Conclusions: Serum concentrations of several PFAS were associated with parathyroid and steroid hormones in both sexes, and with thyroid hormones in boys, as well as with early menarche in girls and higher PDS in boys.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023. Published by Elsevier Inc.)
Databáze: MEDLINE
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