Lactate entrance into the brain facilities adipose tissue lipolysis during exercise via circulating calcitonin gene-related peptide.
| Autor: | Aveseh M; Sport Sciences Department, Shiraz University, Shiraz, Iran.; Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran., Koushkie-Jahromi M; Sport Sciences Department, Shiraz University, Shiraz, Iran., Nemati J; Sport Sciences Department, Shiraz University, Shiraz, Iran., Esmaeili-Mahani S; Department of Biology, Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman, Iran., Hosseini NS; Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Shahid Bahonar University of Kerman, Kerman, Iran. |
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| Jazyk: | angličtina |
| Zdroj: | Archives of physiology and biochemistry [Arch Physiol Biochem] 2024 Dec; Vol. 130 (6), pp. 790-799. Date of Electronic Publication: 2023 Nov 20. |
| DOI: | 10.1080/13813455.2023.2283684 |
| Abstrakt: | Objectives: We assessed the relationships between CGRP, lactate and fat regulation. Methods: We evaluated the effect of intracerebroventricular (i.c.v.) injection of lactate and acute exercise on brain CGRP expression, and its concentration in serum/cerebrospinal fluid (SCF) in rats. Results: Injection of lactate up-regulated CGRP expression in the cortex and CSF and activated p38-mitogen-activated protein kinases (p38-MAPK) pathway. Co-injection of lactate and sb203580, deterred lactate-induced up-regulation of CGRP in the brain and CSF. Exercise increased the CGRP expression in the brain and CSF and up-regulated fat metabolism. Inhibition of lactate entrance into the brain using alpha-cyano-4-hydroxycinnamate (4-CIN) diminished exercise-induced CGRP up-regulation in the brain and CSF. Reducing the circulating blood lactate by pre-treatment of the animals with dichloroacetate (DCA) had no effect on exercise-induced increase in CGRP expression or fat metabolism during exercise. Conclusions: Lactate probably acts as one of a signalling molecule in the brain to regulate fat metabolism during exercise. |
| Databáze: | MEDLINE |
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