NUT Expression Is of Diagnostic Utility in the Distinction of Digital Papillary Carcinoma From Poroid Hidradenoma.

Autor:	Iacobelli J; Anatomical Pathology, PathWest Laboratory Medicine, J Block QEII Medical Centre, Nedlands, Perth, Australia.; The University of Western Australia, Perth, Australia; and., Harvey NT; Anatomical Pathology, PathWest Laboratory Medicine, J Block QEII Medical Centre, Nedlands, Perth, Australia.; The University of Western Australia, Perth, Australia; and., Ardakani NM; Anatomical Pathology, PathWest Laboratory Medicine, J Block QEII Medical Centre, Nedlands, Perth, Australia.; The University of Western Australia, Perth, Australia; and., Ng L; Anatomical Pathology, PathWest Laboratory Medicine, J Block QEII Medical Centre, Nedlands, Perth, Australia.; The University of Western Australia, Perth, Australia; and., Preston H; Fremantle Pathology Level 1, Fremantle, Australia., Wood BA; Anatomical Pathology, PathWest Laboratory Medicine, J Block QEII Medical Centre, Nedlands, Perth, Australia.; The University of Western Australia, Perth, Australia; and.
Jazyk:	angličtina
Zdroj:	The American Journal of dermatopathology [Am J Dermatopathol] 2024 Feb 01; Vol. 46 (2), pp. 98-100. Date of Electronic Publication: 2023 Nov 14.
DOI:	10.1097/DAD.0000000000002596
Abstrakt:	Abstract: The distinction between digital papillary adenocarcinoma (DPAC) and benign cutaneous adnexal tumors is clinically important and can be challenging. Poroid hidradenoma frequently occurs at acral sites and can show a number of histological features, which overlap with digital papillary adenocarcinoma. Recent work has shown that YAP1-NUTM1 fusions are frequent in poroid hidradenoma and are associated with nuclear protein in testis (NUT) expression by immunohistochemistry. We evaluated the expression of NUT-1 by immunohistochemistry in 4 cases of DPAC and 4 cases of poroid hidradenoma. Three of 4 cases of poroid hidradenoma showed strong NUT-1 expression, with no staining in any of the cases of DPAC. These results suggest that NUT-1 immunohistochemistry may be a useful additional tool in evaluating this differential diagnosis. Competing Interests: The authors declare no conflicts of interest. (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu