Sex Differences Among Older Adults With Bipolar Disorder: Results From the Global Aging & Geriatric Experiments in Bipolar Disorder (GAGE-BD) Project.

Autor:	Blanken MAJT; Department of Psychiatry (MAJTB, UMHJ, AD), Amsterdam Neuroscience, Mood Anxiety Psychosis Sleep & Stress Program, Amsterdam, The Netherlands., Oudega ML; Department of Psychiatry (MLO), Amsterdam Neuroscience, Mood Anxiety Psychosis Sleep & Stress Program, Amsterdam Public Health, Mental Health Program, GGZ inGeest, Specialized Mental Health Care, Amsterdam, The Netherlands. Electronic address: m.oudega@ggzingeest.nl., Almeida OP; Medical School (OPA), University of Western Australia, Perth, Australia., Schouws SNTM; GGZ inGeest Specialized Mental Health Care, Old Age Psychiatry (SNTMS, AJMB), Amsterdam Public Health Research Institute, Mental Health, Amsterdam, The Netherlands., Orhan M; Department of Clinical Psychology (MO), Leiden University, Leiden, The Netherlands., Beunders AJM; GGZ inGeest Specialized Mental Health Care, Old Age Psychiatry (SNTMS, AJMB), Amsterdam Public Health Research Institute, Mental Health, Amsterdam, The Netherlands., Klumpers UMH; Department of Psychiatry (MAJTB, UMHJ, AD), Amsterdam Neuroscience, Mood Anxiety Psychosis Sleep & Stress Program, Amsterdam, The Netherlands., Sonnenberg C; GGZ Parnassia NH, Specialized Mental Health Care (CS), Amsterdam Public Health, Mental Health Program, Amsterdam, The Netherlands., Blumberg HP; Department of Psychiatry (HPB), Yale School of Medicine, New Haven, CT., Eyler LT; Department of Psychiatry (LTE), University of California San Diego, USA and Desert-Pacific Mental Illness Research Education and Clinical Center, VA San Diego Healthcare System, San Diego, CA., Forester BP; Division of Geriatric Psychiatry (BPF), McLean Hospital, Harvard Medical School, Boston, MA., Forlenza OV; Laboratory of Neuroscience (LIM-27), Department and Institute of Psychiatry (OVF), HCFMUSP, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil., Gildengers A; Department of Psychiatry (AG), University of Pittsburgh School of Medicine, Pittsburgh, PA., Mulsant BH; Department of Psychiatry (BHM) and Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada., Rajji T; Adult Neurodevelopment and Geriatric Psychiatry Division (TR), Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada., Rej S; Lady Davis Institute/Jewish General Hospital, McGill University, Montreal, Québec, Canada., Sarna K; Case Western Reserve University School of Medicine (KS), Cleveland, OH., Sutherland A; Department of Psychiatry (AS), University of California San Diego, San Diego, CA., Yala J; Case Western Reserve University School of Medicine (JY), Cleveland, OH., Vieta E; Bipolar and Depressive Disorders Unit (EV), Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain., Tsai S; Department of Psychiatry (ST), School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan., Briggs FBS; Department of Public Health Sciences, University of Miami, Miller School of Medicine, Miami, USA., Sajatovic M; Case Western Reserve University School of Medicine (MS), University Hospitals Cleveland Medical Center, Cleveland, OH., Dols A; Department of Psychiatry (MAJTB, UMHJ, AD), Amsterdam Neuroscience, Mood Anxiety Psychosis Sleep & Stress Program, Amsterdam, The Netherlands; Department of Psychiatry (AD), UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, The Netherlands.
Jazyk:	angličtina
Zdroj:	The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry [Am J Geriatr Psychiatry] 2024 Mar; Vol. 32 (3), pp. 326-338. Date of Electronic Publication: 2023 Oct 23.
DOI:	10.1016/j.jagp.2023.10.008
Abstrakt:	Objective: Sex-specific research in adult bipolar disorder (BD) is sparse and even more so among those with older age bipolar disorder (OABD). Knowledge about sex differences across the bipolar lifespan is urgently needed to target and improve treatment. To address this gap, the current study examined sex differences in the domains of clinical presentation, general functioning, and mood symptoms among individuals with OABD. Methods: This Global Aging & Geriatric Experiments in Bipolar Disorder (GAGE-BD) study used data from 19 international studies including BD patients aged ≥50 years (N = 1,185: 645 women, 540 men).A comparison of mood symptoms between women and men was conducted initially using two-tailed t tests and then accounting for systematic differences between the contributing cohorts by performing generalized linear mixed models (GLMMs). Associations between sex and other clinical characteristics were examined using GLMM including: age, BD subtype, rapid cycling, psychiatric hospitalization, lifetime psychiatric comorbidity, and physical health comorbidity, with study cohort as a random intercept. Results: Regarding depressive mood symptoms, women had higher scores on anxiety and hypochondriasis items. Female sex was associated with more psychiatric hospitalizations and male sex with lifetime substance abuse disorders. Conclusion: Our findings show important clinical sex differences and provide support that older age women experience a more severe course of BD, with higher rates of psychiatric hospitalization. The reasons for this may be biological, psychological, or social. These differences as well as underlying mechanisms should be a focus for healthcare professionals and need to be studied further. (Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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