NINJ1 is activated by cell swelling to regulate plasma membrane permeabilization during regulated necrosis.
Autor: | Dondelinger Y; Inflammation Research Center, VIB, Technologiepark 71, 9052, Zwijnaarde-Ghent, Belgium. yves.dondelinger@irc.vib-ugent.be.; Department of Biomedical Molecular Biology, Ghent University, Technologiepark 71, 9052, Zwijnaarde-Ghent, Belgium. yves.dondelinger@irc.vib-ugent.be., Priem D; Inflammation Research Center, VIB, Technologiepark 71, 9052, Zwijnaarde-Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Technologiepark 71, 9052, Zwijnaarde-Ghent, Belgium., Huyghe J; Inflammation Research Center, VIB, Technologiepark 71, 9052, Zwijnaarde-Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Technologiepark 71, 9052, Zwijnaarde-Ghent, Belgium., Delanghe T; Inflammation Research Center, VIB, Technologiepark 71, 9052, Zwijnaarde-Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Technologiepark 71, 9052, Zwijnaarde-Ghent, Belgium., Vandenabeele P; Inflammation Research Center, VIB, Technologiepark 71, 9052, Zwijnaarde-Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Technologiepark 71, 9052, Zwijnaarde-Ghent, Belgium., Bertrand MJM; Inflammation Research Center, VIB, Technologiepark 71, 9052, Zwijnaarde-Ghent, Belgium. mathieu.bertrand@irc.vib-ugent.be.; Department of Biomedical Molecular Biology, Ghent University, Technologiepark 71, 9052, Zwijnaarde-Ghent, Belgium. mathieu.bertrand@irc.vib-ugent.be. |
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Jazyk: | angličtina |
Zdroj: | Cell death & disease [Cell Death Dis] 2023 Nov 18; Vol. 14 (11), pp. 755. Date of Electronic Publication: 2023 Nov 18. |
DOI: | 10.1038/s41419-023-06284-z |
Abstrakt: | Plasma membrane permeabilization (PMP) is a defining feature of regulated necrosis. It allows the extracellular release of damage-associated molecular patterns (DAMPs) that trigger sterile inflammation. The pore forming molecules MLKL and GSDMs drive PMP in necroptosis and pyroptosis, respectively, but the process of PMP remains unclear in many other forms of regulated necrosis. Here, we identified NINJ1 as a crucial regulator of PMP and consequent DAMP release during ferroptosis, parthanatos, H (© 2023. The Author(s).) |
Databáze: | MEDLINE |
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