Association between microbiome and the development of adverse posttraumatic neuropsychiatric sequelae after traumatic stress exposure.

Autor: Zeamer AL; Department of Microbiology and Physiologic Systems, University of Massachusetts Chan Medical School, Worcester, MA, USA., Salive MC; Department of Emergency Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., An X; Institute for Trauma Recovery, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Beaudoin FL; Department of Epidemiology, Brown University, Providence, RI, USA.; Department of Emergency Medicine, Brown University, Providence, RI, USA., House SL; Department of Emergency Medicine, Washington University School of Medicine, St. Louis, MO, USA., Stevens JS; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA., Zeng D; Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA., Neylan TC; Departments of Psychiatry and Neurology, University of California San Francisco, San Francisco, CA, USA., Clifford GD; Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA, USA.; Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA., Linnstaedt SD; Institute for Trauma Recovery, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; The Many Brains Project, Belmont, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA., Rauch SL; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Institute for Technology in Psychiatry, McLean Hospital, Belmont, MA, USA.; Department of Psychiatry, McLean Hospital, Belmont, MA, USA., Storrow AB; Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Lewandowski C; Department of Emergency Medicine, Henry Ford Health System, Detroit, MI, USA., Musey PI Jr; Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN, USA., Hendry PL; Department of Emergency Medicine, University of Florida College of Medicine-Jacksonville, Jacksonville, FL, USA., Sheikh S; Department of Emergency Medicine, University of Florida College of Medicine-Jacksonville, Jacksonville, FL, USA., Jones CW; Department of Emergency Medicine, Cooper Medical School of Rowan University, Camden, NJ, USA., Punches BE; Department of Emergency Medicine, Ohio State University College of Medicine, Columbus, OH, USA.; Ohio State University College of Nursing, Columbus, OH, USA., Swor RA; Department of Emergency Medicine, Oakland University William Beaumont School of Medicine, Rochester, MI, USA., Hudak LA; Department of Emergency Medicine, Emory University School of Medicine, Atlanta, GA, USA., Pascual JL; Department of Surgery, University of Pennsylvania, Philadelphia, PA, USA.; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Seamon MJ; Department of Surgery, University of Pennsylvania, Philadelphia, PA, USA.; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Harris E; Department of Emergency Medicine, Einstein Medical Center, Philadelphia, PA, USA., Pearson C; Department of Emergency Medicine, Wayne State University, Ascension St. John Hospital, Detroit, MI, USA., Peak DA; Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA., Merchant RC; Department of Emergency Medicine, Brigham and Women's Hospital, Boston, MA, USA., Domeier RM; Department of Emergency Medicine, Trinity Health-Ann Arbor, Ypsilanti, MI, USA., Rathlev NK; Department of Emergency Medicine, University of Massachusetts Medical School-Baystate, Springfield, MA, USA., O'Neil BJ; Department of Emergency Medicine, Wayne State University, Detroit Receiving Hospital, Detroit, MI, USA., Sergot P; Department of Emergency Medicine, McGovern Medical School at UTHealth, Houston, TX, USA., Sanchez LD; Department of Emergency Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Emergency Medicine, Harvard Medical School, Boston, MA, USA., Bruce SE; Department of Psychological Sciences, University of Missouri - St. Louis, St. Louis, MO, USA., Kessler RC; Department of Health Care Policy, Harvard Medical School, Boston, MA, USA., Koenen KC; Department of Epidemiology, Harvard University, Boston, MA, USA., McLean SA; Department of Emergency Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Bucci V; Department of Microbiology and Physiologic Systems, University of Massachusetts Chan Medical School, Worcester, MA, USA. vanni.bucci@umassmed.edu.; Program in Microbiome Dynamics, University of Massachusetts Chan Medical School, Worcester, MA, USA. vanni.bucci@umassmed.edu., Haran JP; Department of Microbiology and Physiologic Systems, University of Massachusetts Chan Medical School, Worcester, MA, USA. john.haran@umassmed.edu.; Department of Emergency Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA. john.haran@umassmed.edu.; Program in Microbiome Dynamics, University of Massachusetts Chan Medical School, Worcester, MA, USA. john.haran@umassmed.edu.
Jazyk: angličtina
Zdroj: Translational psychiatry [Transl Psychiatry] 2023 Nov 18; Vol. 13 (1), pp. 354. Date of Electronic Publication: 2023 Nov 18.
DOI: 10.1038/s41398-023-02643-8
Abstrakt: Patients exposed to trauma often experience high rates of adverse post-traumatic neuropsychiatric sequelae (APNS). The biological mechanisms promoting APNS are currently unknown, but the microbiota-gut-brain axis offers an avenue to understanding mechanisms as well as possibilities for intervention. Microbiome composition after trauma exposure has been poorly examined regarding neuropsychiatric outcomes. We aimed to determine whether the gut microbiomes of trauma-exposed emergency department patients who develop APNS have dysfunctional gut microbiome profiles and discover potential associated mechanisms. We performed metagenomic analysis on stool samples (n = 51) from a subset of adults enrolled in the Advancing Understanding of RecOvery afteR traumA (AURORA) study. Two-, eight- and twelve-week post-trauma outcomes for post-traumatic stress disorder (PTSD) (PTSD checklist for DSM-5), normalized depression scores (PROMIS Depression Short Form 8b) and somatic symptom counts were collected. Generalized linear models were created for each outcome using microbial abundances and relevant demographics. Mixed-effect random forest machine learning models were used to identify associations between APNS outcomes and microbial features and encoded metabolic pathways from stool metagenomics. Microbial species, including Flavonifractor plautii, Ruminococcus gnavus and, Bifidobacterium species, which are prevalent commensal gut microbes, were found to be important in predicting worse APNS outcomes from microbial abundance data. Notably, through APNS outcome modeling using microbial metabolic pathways, worse APNS outcomes were highly predicted by decreased L-arginine related pathway genes and increased citrulline and ornithine pathways. Common commensal microbial species are enriched in individuals who develop APNS. More notably, we identified a biological mechanism through which the gut microbiome reduces global arginine bioavailability, a metabolic change that has also been demonstrated in the plasma of patients with PTSD.
(© 2023. The Author(s).)
Databáze: MEDLINE
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