The effect of SARS-CoV-2 virus on resting-state functional connectivity during adolescence: Investigating brain correlates of psychotic-like experiences and SARS-CoV-2 related inflammation response.

Autor: Kafali HY; Department of Psychology, Fevziye Schools Fundation, Işık University, Istanbul, Turkey., Dasgin H; National Magnetic Resonance Research Center (UMRAM), Bilkent University, Ankara, Turkey., Sahin Cevik D; National Magnetic Resonance Research Center (UMRAM), Bilkent University, Ankara, Turkey., Sozan SS; Department of Psychology, Ankara Social Sciences University, Ankara, Turkey., Oguz KK; National Magnetic Resonance Research Center (UMRAM), Bilkent University, Ankara, Turkey; School of Medicine, Department of Radiology, University of California Davis, United States., Mutlu M; Department of Child Psychiatry, Ankara City Hospital, Ankara, Turkey., Parlakay AO; Department of Pediatric Infectious Diseases, Ankara City Hospital, Ankara, Turkey., Toulopoulou T; National Magnetic Resonance Research Center (UMRAM), Bilkent University, Ankara, Turkey; Department of Psychology, Bilkent University, Ankara, Turkey; Department of Psychiatry, National and Kapodistrian University of Athens, Athens, Greece; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, United States. Electronic address: timothea.toulopoulou@mssm.edu.
Jazyk: angličtina
Zdroj: Psychiatry research. Neuroimaging [Psychiatry Res Neuroimaging] 2023 Dec; Vol. 336, pp. 111746. Date of Electronic Publication: 2023 Nov 05.
DOI: 10.1016/j.pscychresns.2023.111746
Abstrakt: We first aimed to investigate resting-state functional connectivity (rs-FC) differences between adolescents exposed to SARS-CoV-2 and healthy controls. Secondly, the moderator effect of PLEs on group differences in rs-FC was examined. Thirdly, brain correlates of inflammation response during acute SARS-CoV-2 infection were investigated. Eighty-two participants aged between 14 and 24 years (SARS-CoV-2 (n = 35), controls (n = 47)) were examined using rs-fMRI. Seed-based rs-FC analysis was performed. The positive subscale of Community Assessment of Psychotic Experiences-42 (CAPE-Pos) was used to measure PLEs. The SARS-CoV-2 group had a lesser rs-FC within sensorimotor network (SMN), central executive network (CEN) and language network (LN), but an increased rs-FC within visual network (VN) compared to controls. No significant differences were detected between the groups regarding CAPE-Pos-score. However, including CAPE-Pos as a covariate, we found increased rs-FC within CEN and SN in SARS-CoV-2 compared to controls. Among the SARS-CoV-2 group, neutrophil/lymphocyte and thrombocyte*neutrophil/lymphocyte ratio was correlated with decreased/increased FC within DMN and SN, and increased FC within CEN. Our results showed rs-FC alterations within the SMN, CEN, LN, and VN among adolescents exposed to SARS-CoV-2. Moreover, changes in rs-FC associated with PLEs existed in these adolescents despite the absence of clinical changes. Furthermore, inflammation response was correlated with alterations in FC within the triple network system.
Competing Interests: Declaration of Competing Interest None declared.
(Copyright © 2023. Published by Elsevier B.V.)
Databáze: MEDLINE
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