From mother to child: How intergenerational transfer is reflected in similarity of corticolimbic brain structure and mental health.

Autor:	Dimanova P; Jacobs Center for Productive Youth Development, University of Zurich, Zurich, Switzerland; Neuroscience Center Zurich, University and ETH Zurich, Zurich, Switzerland. Electronic address: plamina.dimanova@jacobscenter.uzh.ch., Borbás R; Jacobs Center for Productive Youth Development, University of Zurich, Zurich, Switzerland., Raschle NM; Jacobs Center for Productive Youth Development, University of Zurich, Zurich, Switzerland; Neuroscience Center Zurich, University and ETH Zurich, Zurich, Switzerland. Electronic address: nora.raschle@jacobscenter.uzh.ch.
Jazyk:	angličtina
Zdroj:	Developmental cognitive neuroscience [Dev Cogn Neurosci] 2023 Dec; Vol. 64, pp. 101324. Date of Electronic Publication: 2023 Nov 11.
DOI:	10.1016/j.dcn.2023.101324
Abstrakt:	Background: Intergenerational transfer effects include traits transmission from parent to child. While behaviorally well documented, studies on intergenerational transfer effects for brain structure or functioning are scarce, especially those examining relations of behavioral and neurobiological endophenotypes. This study aims to investigate behavioral and neural intergenerational transfer effects associated with the corticolimbic circuitry, relevant for socioemotional functioning and mental well-being. Methods: T1-neuroimaging and behavioral data was obtained from 72 participants (39 mother-child dyads/ 39 children; 7-13 years; 16 girls/ 33 mothers; 26-52 years). Gray matter volume (GMV) was extracted from corticolimbic regions (subcortical: amygdala, hippocampus, nucleus accumbens; neocortical: anterior cingulate, medial orbitofrontal areas). Mother-child similarity was quantified by correlation coefficients and comparisons to random adult-child pairs. Results: We identified significant corticolimbic mother-child similarity (r = 0.663) stronger for subcortical over neocortical regions. Mother-child similarity in mental well-being was significant (r = 0.409) and the degree of dyadic similarity in mental well-being was predicted by similarity in neocortical, but not subcortical GMV. Conclusion: Intergenerational neuroimaging reveals significant mother-child transfer for corticolimbic GMV, most strongly for subcortical regions. However, variations in neocortical similarity predicted similarity in mother-child well-being. Ultimately, such techniques may enhance our knowledge of behavioral and neural familial transfer effects relevant for health and disease. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023. Published by Elsevier Ltd.)
Databáze:	MEDLINE
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