Analysis of NAPA Gene Expression in Brain Structures of Wistar Rats during the Formation of Long-Term Spatial Memory and Physical Activity under Stress Situation.

Autor: Gruden MA; P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia. mgruden@mail.ru., Ratmirov AM; P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia., Storozheva ZI; P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia., Sewell RDE; Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, UK.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2023 Oct; Vol. 175 (6), pp. 810-813. Date of Electronic Publication: 2023 Nov 18.
DOI: 10.1007/s10517-023-05952-6
Abstrakt: In the cerebellum, hippocampus, and prefrontal cortex of mature male Wistar rats with trained spatial navigational skill in the Morris water maze, the transcriptional activity the NAPA gene that regulates the transport and secretion of synaptic vesicles, release of neurotransmitters, and protein degradation was determined by real-time PCR. Animals subjected to forced swimming in a time-matched regime (active control) and naïve rats were used as the comparison groups. Suppression of NAPA gene activity was found in the hippocampus and cerebellum of the active control group, while navigation skill training led to a significant increase in gene expression in all brain structures under study. The findings suggest the existence of specific mechanisms regulating NAPA gene activity during the formation of spatial memory and adaptive behavior under stress conditions.
(© 2023. Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
Externí odkaz: