Highlights of three metabolites HDL and reduction in blood pressure values after dietary fiber supplementation in overweight and obese normotensive women: a metabolomic study.

Autor: da Silva CSO; Postgraduate Program in Nutrition Sciences, Federal University of Paraíba, João, Pessoa, 58059-900, Brazil. suramajpa3@hotmail.com., Monteiro MGCA; Postgraduate Program in Nutrition Sciences, Federal University of Paraíba, João, Pessoa, 58059-900, Brazil., Fechine CPNDS; Postgraduate Program in Nutrition Sciences, Federal University of Paraíba, João, Pessoa, 58059-900, Brazil., Tavares JF; Department of Pharmaceutical Sciences, Federal University of Paraiba, João, Pessoa, 58059-900, Brazil., Souto AL; Department of Pharmaceutical Sciences, Federal University of Paraiba, João, Pessoa, 58059-900, Brazil., Luna RCP; Postgraduate Program in Nutrition Sciences, Federal University of Paraíba, João, Pessoa, 58059-900, Brazil., Pimenta FCF; Department of Internal Medicine, Federal University of Paraiba, João, Pessoa, 58059-900, Brazil., E Silva AHA; Department of Statistics, Centre for Exact and Natural Sciences, Federal University of Paraiba, João, Pessoa, 58059-900, Brazil., da Silva Diniz A; Department of Nutrition, Health Sciences Center, Federal University of Pernambuco, Recife, 50670-901, Brazil., da Silva Júnior CC; Postgraduate Program in Nutrition Sciences, Federal University of Paraíba, João, Pessoa, 58059-900, Brazil., Alverga CCF; Postgraduate Program in Public health, Federal University of Paraíba, João, Pessoa, 58059-900, Brazil., Dos Santos SG; Department of Pharmaceutical Sciences, Federal University of Paraiba, João, Pessoa, 58059-900, Brazil., Persuhn DC; Postgraduate Program in Nutrition Sciences, Federal University of Paraíba, João, Pessoa, 58059-900, Brazil., de Carvalho Costa MJ; Postgraduate Program in Nutrition Sciences, Federal University of Paraíba, João, Pessoa, 58059-900, Brazil.
Jazyk: angličtina
Zdroj: Metabolomics : Official journal of the Metabolomic Society [Metabolomics] 2023 Nov 17; Vol. 19 (12), pp. 95. Date of Electronic Publication: 2023 Nov 17.
DOI: 10.1007/s11306-023-02057-z
Abstrakt: Introduction: The prevalence of hypertension and obesity are a worldwide concern.
Objetives: Assess the metabolites profile after intervention with mixed dietary fiber in overweight and obese normotensive women.
Methods: This is a randomized double blind placebo-controlled study. Through a simple randomization process, two groups were allocated, with eleven women (group 1) receiving 12 g of mixed dietary fiber and thirteen women (group 2) receiving 12 g of placebo (corn starch) for eight weeks. Anthropometric and biochemical tests and lifestyle were analyzed. As for evaluation metabolomics, used a 1 H NMR. The data matrix generated 96 samples and 225 variables, which was exported in the ASCII format for the "The Unscrumbler" statistics software (version 9.7, CAMO Process).
Results: After the intervention with mixed dietary fiber, significant differences were observed between the main types of metabolites, referring to the increase in the relative peak areas of in three HDL metabolites 4.94 ppm (0.0086*), HDL 1.28 ppm (0 .0337*), HDL 0.88 ppm (0.0224*) and an α-glucose metabolite 4.90 ppm (0.0106) and the reduction in systolic blood pressure (SBP) (0.0292*) of 7 mmHg in the reference range and in the placebo group there was a reduction in SBP (0.0118*) of 4 mmHg and of a choline metabolite 3.65 ppm (0.0266*), which does not call into question the validity of these results in the literature.
Conclusion: The synergism of the functions of these statistically highlighted metabolites contributed to prevention the increase in SBP after fiber intervention in overweight and obese normotensive women.
(© 2023. The Author(s).)
Databáze: MEDLINE
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