Intraventricular baclofen for palliative management of acquired generalized dystonia in pediatric patients: a case series and literature review.

Autor: Krouma M; Division of Neurosurgery, Department of Pediatric Neurosurgery, La Timone Hospital, Aix-Marseille University, Marseille, France., Soilhi AA; Division of Neurosurgery, Department of Pediatric Neurosurgery, La Timone Hospital, Aix-Marseille University, Marseille, France., Desnous B; Department of Pediatric Neurology, La Timone Hospital, Aix Marseille University, Marseille, France., James S; Department of Pediatric Neurosurgery, Division of Neurosurgery, Necker Hospital, Paris, France., Boulay C; Department of Pediatric Neurology, La Timone Hospital, Aix Marseille University, Marseille, France., Scavarda D; Division of Neurosurgery, Department of Pediatric Neurosurgery, La Timone Hospital, Aix-Marseille University, Marseille, France. didier.scavarda@ap-hm.fr.
Jazyk: angličtina
Zdroj: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery [Childs Nerv Syst] 2024 Mar; Vol. 40 (3), pp. 895-903. Date of Electronic Publication: 2023 Nov 17.
DOI: 10.1007/s00381-023-06217-3
Abstrakt: Dystonia represents a significant source of disability in children. Generalized dystonia, which involves multiple body regions, leads to impaired mobility and motor function, resulting in substantial challenges in daily activities. Surgical treatments are used when medical treatments fail. Intrathecal baclofen (ITB) or deep brain stimulations (DBS) are the most employed surgical therapies. When these options are not feasible or ineffective, some authors have explored the use of intraventricular baclofen (IVB). In this report, we present four cases of pediatric patients with generalized dystonia who underwent treatment with IVB, resulting in notable improvements. To further explore the potential of this treatment modality, we conducted a comprehensive literature review. The findings from our study provide a comprehensive overview that can guide palliative management in similar cases.
(© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
Externí odkaz: