Variation of Plasma Damage-Associated Molecular Patterns in Patients with Advanced Solid Tumors after Standard of Care Systemic Treatment.
Autor: | Valentí V; Medical Oncology, Hospital Santa Tecla, Tarragona, Spain., Capdevila L; Medical Oncology, Hospital Santa Tecla, Tarragona, Spain., Ruiz I; Medical Oncology, Hospital del Vendrell, El Vendrell, Spain., Ramos J; Medical Oncology, Hospital Santa Tecla, Tarragona, Spain., Badía J; Medical Oncology, Hospital Santa Tecla, Tarragona, Spain., Blázquez S; Pahology Department, Hospital Santa Tecla, Tarragona, Spain., Villuendas Ó; Clinical Laboratory, Hospital Santa Tecla, Tarragona, Spain., Pérez C; Medical Oncology, Hospital del Vendrell, El Vendrell, Spain., Fernández-Sender L; Internal Medicine, Hospital Santa Tecla, Tarragona, Spain., Córdoba M; Internal Medicine, Hospital Santa Tecla, Tarragona, Spain., Alonso-Villaverde C; Internal Medicine, Hospital Santa Tecla, Tarragona, Spain. |
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Jazyk: | angličtina |
Zdroj: | Cancer investigation [Cancer Invest] 2023 Dec; Vol. 41 (10), pp. 821-829. Date of Electronic Publication: 2024 Jan 02. |
DOI: | 10.1080/07357907.2023.2283458 |
Abstrakt: | Background: Immunogenic cell death (ICD) is known for releasing damage-associated molecular patterns (DAMPs) from tumor cells. We aimed to find ICD signals by assessing the variation of plasmatic DAMPs (HMGB1, S100A8) before-after standard of care (SoC) systemic treatment in patients with advanced solid tumors. Methods: Patients scheduled to start a new line of systemic treatment were included. Plasmatic concentrations of HMGB1 and S100A8 were measured (ng/mL) before and after three months of treatment. Results: Fifty-two patients were included. Forty-four patients (85%) had metastases, and 8 (15%) were treated for stage III tumors. The most frequent tumor sites were colorectal (35%) and lung (25%). Forty-two patients (81%) received this treatment in the first-line setting. Thirty-six patients (69%) were treated chemotherapy (CT) alone, ten (19%) CT plus targeted therapy, two (3.8%) carboplatin-pemetrexed-pembrolizumab, three (5.8%) pembrolizumab alone and one (1.9%) cetuximab alone. Median plasmatic concentration of S100A8 was significantly higher before than after treatment in the whole population (3.78 vs. 2.91 ng/mL; p = 0.011) and more markedly in the subgroups of patients who experienced RECIST-assessed tumor response (5.70 vs. 2.63 ng/mL; p = 0.002). Median plasmatic concentration of HMGB1was not significantly different before and after treatment (10.23 vs. 11.85 ng/mL; p = 0.382) and did not differ depending on tumor response. Median PFS was not significantly different between patients whose plasma HMBG1 concentration decreased or increased (8.0 vs. 10.6 months; p = 0.29) after treatment. Median PFS was significantly longer in those patients in whom the plasma concentration of S100A8 decreased after treatment (12 vs. 4.7 months; p < 0.001). Median OS was not significantly different between patients whose plasma HMBG1 concentration decreased or increased (13.1 vs. 14.7 months; p = 0.46) after treatment. Median OS was significantly longer in those patients in whom the plasma concentration of S100A8 decreased after treatment (16.7 vs. 9.0 months; p < 0.001). Conclusions: Signals of ICD were not observed. S100A8 behaves as an inflammatory marker with decreased concentration after treatment, mostly in RECIST-responders. PFS and OS were significantly prolonged in those patients who experienced a decrease of S100A8 compared with those patients who experienced increase of plasma S100A8 at three months. |
Databáze: | MEDLINE |
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