Individual meropenem epithelial lining fluid and plasma PK/PD target attainment.
Autor: | Rohani R; Discipline of Cellular and Molecular Pharmacology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA., Yarnold PR; Optimal Data Analysis, LLC, Chicago, Illinois, USA., Scheetz MH; Department of Pharmacy Practice, Midwestern University, Chicago College of Pharmacy, Downers Grove, Illinois, USA.; Pharmacometrics Center of Excellence, Midwestern University, Downers Grove, Illinois, USA.; Department of Pharmacy, Northwestern Memorial Hospital, Chicago, Illinois, USA., Neely MN; Laboratory of Applied Pharmacokinetics and Bioinformatics, The Saban Research Institute, Children's Hospital of Los Angeles, Los Angeles, California, USA.; Keck School of Medicine, University of Southern California, Los Angeles, California, USA., Kang M; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Donnelly HK; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Dedicatoria K; Department of Pharmacy Practice, Midwestern University, Chicago College of Pharmacy, Downers Grove, Illinois, USA., Nozick SH; Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Medernach RL; Division of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Hauser AR; Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Division of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Ozer EA; Division of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Center for Pathogen Genomics and Microbial Evolution, Havey Institute for Global Health, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Diaz E; Robert H. Lurie Comprehensive Cancer Research Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Misharin AV; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Wunderink RG; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Rhodes NJ; Department of Pharmacy Practice, Midwestern University, Chicago College of Pharmacy, Downers Grove, Illinois, USA.; Pharmacometrics Center of Excellence, Midwestern University, Downers Grove, Illinois, USA.; Department of Pharmacy, Northwestern Memorial Hospital, Chicago, Illinois, USA. |
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Jazyk: | angličtina |
Zdroj: | Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2023 Dec 14; Vol. 67 (12), pp. e0072723. Date of Electronic Publication: 2023 Nov 17. |
DOI: | 10.1128/aac.00727-23 |
Abstrakt: | It is unclear whether plasma is a reliable surrogate for target attainment in the epithelial lining fluid (ELF). The objective of this study was to characterize meropenem target attainment in plasma and ELF using prospective samples. The first 24-hour T Competing Interests: The authors declare no conflict of interest. |
Databáze: | MEDLINE |
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