Association between oxidative stress, antioxidant enzymes, and homocysteine in patients with polycystic ovary syndrome.

Autor:	Alfeel AH; Department of Medical Laboratory Sciences, College of Health Sciences, Gulf Medical University, Ajman, United Arab Emirates. M.Ahmed@sharjah.ac.ae., Hussein SEO, Elsayed Yousif TY, Babker AMA, Alamin Altoum AE, Mohamed AN, Elzein HO, Ahmed T, Saboor M, Osman HA, Kumar P, Ali H, Abdalhabib EK
Jazyk:	angličtina
Zdroj:	European review for medical and pharmacological sciences [Eur Rev Med Pharmacol Sci] 2023 Nov; Vol. 27 (21), pp. 10631-10641.
DOI:	10.26355/eurrev_202311_34343
Abstrakt:	Objective: Polycystic ovary syndrome (PCOS) is a prevalent health condition that commonly affects adolescent girls and young women. The purpose of this study was to evaluate the correlation between levels of total glutathione (TG), reduced glutathione (GSH), superoxide dismutase (SOD), lipid peroxidation, and homocysteine with PCOS. Patients and Methods: This study employed a cross-sectional case-control design, involving a target population of 305 Sudanese females. Among them, 205 individuals were categorized as cases, and 100 served as controls. The TG, GSH, SOD, lipid peroxidation, and homocysteine levels were measured in the serum of study participants through enzyme-linked immunosorbent essay. Results: Total glutathione (1,174.5 ± 271.4 vs. 986.1 ± 191.5, p = 0.01), GSH (801.3 ± 132.2 vs. 748.6 ± 103.1, p = 0.007), SOD (225.2 ± 57.8 vs. 195.5 ± 49.6, p = 0.009), lipid peroxidation (3.4 ± 1.1 vs. 2.4 ± 0.7, p = 0.03), and homocysteine (14.9 ± 2.1 vs. 13.5 ± 1.6, p = 0.04), showed significant differences between the two groups (cases vs. controls). A moderate positive correlation between TG, GSH, SOD, lipid peroxidation, homocysteine, BMI, age, and duration of PCOS was observed. Furthermore, a strong positive correlation between BMI, age, and duration of PCOS was noted within the patient group. Conclusions: In conclusion, this study demonstrates that patients with PCOS have elevated levels of TG, GSH, SOD, lipid peroxidation, and homocysteine compared to the control group. These findings suggest a potential association between PCOS and oxidative stress, lipid metabolism, and homocysteine pathways. Moreover, the observed positive correlation with BMI, age, and duration of PCOS indicates the importance of these factors in disease progression.
Databáze:	MEDLINE
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