Blood glucose lowering and anti-oxidant potential of erythritol: An in vitro and in vivo study.

Autor: Soetan OA; Reproduction and Bionformatics Research Unit, Ladoke Akintola University of Technology, Ogbomosho, Oyo Nigeria.; Department of Physiology, Ladoke Akintola University of Technology, Ogbomosho, Oyo Nigeria.; Department of Physiology, Faculty of Basic Medical Sciences, Thomas Adewumi University, Oko, Kwara State Nigeria., Ajao FO; Reproduction and Bionformatics Research Unit, Ladoke Akintola University of Technology, Ogbomosho, Oyo Nigeria.; Department of Physiology, Ladoke Akintola University of Technology, Ogbomosho, Oyo Nigeria., Ajayi AF; Reproduction and Bionformatics Research Unit, Ladoke Akintola University of Technology, Ogbomosho, Oyo Nigeria.; Department of Physiology, Ladoke Akintola University of Technology, Ogbomosho, Oyo Nigeria.
Jazyk: angličtina
Zdroj: Journal of diabetes and metabolic disorders [J Diabetes Metab Disord] 2023 May 29; Vol. 22 (2), pp. 1217-1229. Date of Electronic Publication: 2023 May 29 (Print Publication: 2023).
DOI: 10.1007/s40200-023-01237-x
Abstrakt: Background: Diabetes is a major cause of death worldwide and Nigeria is not an exception. The quest to lower sugar levels has become a major factor in the management of diabetes; this has occasioned the use of substitutes for refined sugar in beverages. Erythritol is a natural sweetener gaining immense interest in recent times. Like metformin, erythritol has shown hydroxyl radical scavenging ability and has metabolic profile suitable for diabetics. Therefore, the blood glucose-lowering and anti-oxidant properties of erythritol under in vitro and in vivo systems were accessed.
Methods: Radical scavenging assay (ABTS and DPPH) and inhibition of carbohydrate digestive enzymes (alpha-amylase and alpha-glucosidase) were employed to determine in vitro anti-oxidant and glucose regulatory function of erythritol respectively. Molecular docking studies were performed between 3D structures of human pancreatic alpha-amylase and alpha-glucosidase, isomaltase from saccharomyces cerevisiae with erythritol. The drug-like activity of erythritol was also assessed.Thereafter, we investigated the effect of erythritol on blood glucose and antioxidant status of normal and streptozocin- nicotinamide-induced diabetes rats which were grouped into five (n = 5); Normal, Ery (normal and administered erythritol), Db (diabetic control), Db + Ery (diabetic and administered erythritol), and Db + Met (diabetic and administered metformin).
Results: Erythritol showed a considerable radical scavenging activity and an ability to inhibit alpha-amylase and alpha-glucosidase in vitro. Also, a significant reduction in glucose intolerance, blood glucose and hemoglobin A1c levels and improved antioxidant level was seen in erythritol-treated diabetic rats.
Conclusion: Erythritol showed anti-oxidant activity, alpha amylase and glucosidase enzyme inhibition property, improved antioxidant status and ameliorated blood glucose, HbA1c, and glucose intolerance following diabetes.
Competing Interests: Conflict of interestNo conflict of interest to declare.
(© The Author(s), under exclusive licence to Tehran University of Medical Sciences 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.)
Databáze: MEDLINE
Externí odkaz: