Cyanoarylporphyrazine dyes: multimodal compounds for personalised photodynamic therapy.

Autor: Shilyagina NY; Institute of Biology and Biomedicine, Lobachevsky State University, Gagarin Ave., 23, 603022 Nizhny Novgorod, Russia., Shestakova LN; Institute of Biology and Biomedicine, Lobachevsky State University, Gagarin Ave., 23, 603022 Nizhny Novgorod, Russia.; Razuvaev Institute of Organometallic Chemistry, Russian Academy of Sciences, Tropinin str., 49, 603137 Nizhny Novgorod, Russia., Peskova NN; Institute of Biology and Biomedicine, Lobachevsky State University, Gagarin Ave., 23, 603022 Nizhny Novgorod, Russia., Lermontova SA; Razuvaev Institute of Organometallic Chemistry, Russian Academy of Sciences, Tropinin str., 49, 603137 Nizhny Novgorod, Russia., Lyubova TS; Razuvaev Institute of Organometallic Chemistry, Russian Academy of Sciences, Tropinin str., 49, 603137 Nizhny Novgorod, Russia., Klapshina LG; Razuvaev Institute of Organometallic Chemistry, Russian Academy of Sciences, Tropinin str., 49, 603137 Nizhny Novgorod, Russia., Balalaeva IV; Institute of Biology and Biomedicine, Lobachevsky State University, Gagarin Ave., 23, 603022 Nizhny Novgorod, Russia.
Jazyk: angličtina
Zdroj: Biophysical reviews [Biophys Rev] 2023 Sep 25; Vol. 15 (5), pp. 971-982. Date of Electronic Publication: 2023 Sep 25 (Print Publication: 2023).
DOI: 10.1007/s12551-023-01134-w
Abstrakt: Photodynamic therapy is known as an effective primary and adjuvant anticancer treatment. Compounds with improved properties or additional modalities are still needed to create an 'ideal' photosensitizer. In this article, we review cyanoarylporphyrazine dyes for photodynamic (anticancer) therapy that we have synthesised to date. The review provides information on the chemistry of cyanoarylporphyrazines, photophysical properties, cellular uptake features and the use of various carriers for selective delivery of cyanoarylporphyrazines to the tumour. The potential of cyanoarylporphyrazines as photodynamic anti-tumour agents also has been evaluated. The most interesting feature of cyanoarylporphyrazines is the dependence of the fluorescence quantum yield and excited state lifetime on the viscosity of the medium, which makes it possible to use them as viscosity sensors in photodynamic therapy. In the future, we expect that the unique combination of photosensitizer and viscosity sensor properties of cyanoarylporphyrazines will provide a tool for dosimetry and tailoring treatment regimens in photodynamic therapy to the individual characteristics of each patient.
Competing Interests: Competing interestsThe authors declare no competing interests.
(© International Union for Pure and Applied Biophysics (IUPAB) and Springer-Verlag GmbH Germany, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.)
Databáze: MEDLINE
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