Novel biocatalysts based on enzymes in complexes with nano- and micromaterials.

Autor: Holyavka MG; Voronezh State University, Voronezh, 394018 Russia.; Sevastopol State University, Sevastopol, 299053 Russia., Goncharova SS; Voronezh State University, Voronezh, 394018 Russia., Redko YA; Voronezh State University, Voronezh, 394018 Russia., Lavlinskaya MS; Voronezh State University, Voronezh, 394018 Russia.; Sevastopol State University, Sevastopol, 299053 Russia., Sorokin AV; Voronezh State University, Voronezh, 394018 Russia.; Sevastopol State University, Sevastopol, 299053 Russia., Artyukhov VG; Voronezh State University, Voronezh, 394018 Russia.
Jazyk: angličtina
Zdroj: Biophysical reviews [Biophys Rev] 2023 Oct 03; Vol. 15 (5), pp. 1127-1158. Date of Electronic Publication: 2023 Oct 03 (Print Publication: 2023).
DOI: 10.1007/s12551-023-01146-6
Abstrakt: In today's world, there is a wide array of materials engineered at the nano- and microscale, with numerous applications attributed to these innovations. This review aims to provide a concise overview of how nano- and micromaterials are utilized for enzyme immobilization. Enzymes act as eco-friendly biocatalysts extensively used in various industries and medicine. However, their widespread adoption faces challenges due to factors such as enzyme instability under different conditions, resulting in reduced effectiveness, high costs, and limited reusability. To address these issues, researchers have explored immobilization techniques using nano- and microscale materials as a potential solution. Such techniques offer the promise of enhancing enzyme stability against varying temperatures, solvents, pH levels, pollutants, and impurities. Consequently, enzyme immobilization remains a subject of great interest within both the scientific community and the industrial sector. As of now, the primary goal of enzyme immobilization is not solely limited to enabling reusability and stability. It has been demonstrated as a powerful tool to enhance various enzyme properties and improve biocatalyst performance and characteristics. The integration of nano- and microscale materials into biomedical devices is seamless, given the similarity in size to most biological systems. Common materials employed in developing these nanotechnology products include synthetic polymers, carbon-based nanomaterials, magnetic micro- and nanoparticles, metal and metal oxide nanoparticles, metal-organic frameworks, nano-sized mesoporous hydrogen-bonded organic frameworks, protein-based nano-delivery systems, lipid-based nano- and micromaterials, and polysaccharide-based nanoparticles.
Competing Interests: Conflict of interestThe authors declare no competing interests.
(© International Union for Pure and Applied Biophysics (IUPAB) and Springer-Verlag GmbH Germany, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.)
Databáze: MEDLINE
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