Mechanisms of UV-induced human lymphocyte apoptosis.

Autor: Nakvasina MA; Voronezh State University, Voronezh, 394018 Russia., Holyavka MG; Voronezh State University, Voronezh, 394018 Russia., Artyukhov VG; Voronezh State University, Voronezh, 394018 Russia., Radchenko MS; Voronezh State Medical University, Voronezh, 394036 Russia., Lidokhova OV; Voronezh State Medical University, Voronezh, 394036 Russia.
Jazyk: angličtina
Zdroj: Biophysical reviews [Biophys Rev] 2023 Sep 14; Vol. 15 (5), pp. 1257-1267. Date of Electronic Publication: 2023 Sep 14 (Print Publication: 2023).
DOI: 10.1007/s12551-023-01142-w
Abstrakt: The article reviews the results of the studies of marker parameters (indicators) of various pathways and mechanisms of apoptosis of lymphocytes in donor peripheral blood induced by UV light (240-390 nm) in doses of 151, 1510, and 3020 J/m 2 . The article analyses the processes of DNA fragmentation, distortion of the structural asymmetry of the cell membranes, changes in the degree of DNA damage (single-strand breaks), transcriptional factor р53, cytochrome с , Fas receptors (CD95), caspase-3, caspase-8, and caspase-9, reactive oxygen species, and calcium ions in UV modified cells. The study determined that programmed cell death of lymphocytes after UV irradiation with 1510 J/m 2 involves the р53-dependent pathway of the nuclear mechanism, as well as receptor-mediated caspase mechanism, mitochondrial mechanism, and the mechanism associated with the defects in calcium homeostasis. Cell death is mediated by reactive oxygen and calcium ions. The article suggests a scheme of possible intracellular events resulting in the apoptotic death of lymphocytes after UV irradiation.
Competing Interests: Conflict of interestThe authors declare no competing interests.
(© International Union for Pure and Applied Biophysics (IUPAB) and Springer-Verlag GmbH Germany, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.)
Databáze: MEDLINE
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