Near complete genome sequences from Southern Vietnam revealed local features of genetic diversity and intergenerational changes in SARS- CoV-2 variants in 2020-2021.
Autor: | Gladkikh AS; Saint Petersburg Pasteur Institute, 14 Mira Street, Saint Petersburg, 197101, Russia., Cao TM; Pasteur Institute in Ho Chi Minh City, Ho Chi Minh City, Vietnam., Klyuchnikova EO; Saint Petersburg Pasteur Institute, 14 Mira Street, Saint Petersburg, 197101, Russia. ekaterina.ibg@gmail.com., Dao MH; Pasteur Institute in Ho Chi Minh City, Ho Chi Minh City, Vietnam., Sharova AA; Saint Petersburg Pasteur Institute, 14 Mira Street, Saint Petersburg, 197101, Russia., Melnichenko VD; Saint Petersburg Pasteur Institute, 14 Mira Street, Saint Petersburg, 197101, Russia., Popova MR; Saint Petersburg Pasteur Institute, 14 Mira Street, Saint Petersburg, 197101, Russia., Arbuzova TV; Saint Petersburg Pasteur Institute, 14 Mira Street, Saint Petersburg, 197101, Russia., Sbarzaglia VA; Saint Petersburg Pasteur Institute, 14 Mira Street, Saint Petersburg, 197101, Russia., Tsyganova NA; Saint Petersburg Pasteur Institute, 14 Mira Street, Saint Petersburg, 197101, Russia., Ramsay E; Saint Petersburg Pasteur Institute, 14 Mira Street, Saint Petersburg, 197101, Russia., Dedkov VG; Saint Petersburg Pasteur Institute, 14 Mira Street, Saint Petersburg, 197101, Russia.; Martsinovsky Institute of Medical Parasitology, Tropical and Vector Borne Diseases, Sechenov First Moscow State Medical University, Moscow, Russia. |
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Jazyk: | angličtina |
Zdroj: | BMC infectious diseases [BMC Infect Dis] 2023 Nov 17; Vol. 23 (1), pp. 806. Date of Electronic Publication: 2023 Nov 17. |
DOI: | 10.1186/s12879-023-08814-8 |
Abstrakt: | Background: Since its beginnings in 2019, the COVID-19 pandemic is still a problem of global medical concern. Southern Vietnam is one of the country's vast regions, including 20 provinces and the densely populated metropolis Ho Chi Minh City. A randomized retrospective study was performed to investigate the epidemiology and genetic diversity of COVID-19. Whole-genome sequencing of 126 SARS-CoV-2 samples collected from Southern Vietnam between January 2020 and December 2021 revealed the main circulating variants and their distribution. Methods: Epidemiological data were obtained from the Department of Preventive Medicine of the Vietnamese Ministry of Health. To identify circulating variants, RNA, extracted from 126 nasopharyngeal swabs of patients with suspected COVID-19 were sequenced on Illunina MiSeq to obtain near complete genomes SARS-CoV-2. Results: Due to the effectiveness of restrictive measures in Vietnam, it was possible to keep incidence at a low level. The partial relaxation of restrictive measures, and the spread of Delta lineages, contributed to the beginning of a logarithmic increase in incidence. Lineages 20A-H circulated in Southern Vietnam during 2020. Spread of the Delta lineage in Southern Vietnam began in March 2021, causing a logarithmic rise in the number of COVID-19 cases. Conclusions: Pandemic dynamics in Southern Vietnam feature specific variations in incidence, and these reflect the success of the restrictive measures put in place during the early stages of the pandemic. (© 2023. The Author(s).) |
Databáze: | MEDLINE |
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